Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) restrict oral availability and brain accumulation of the PARP inhibitor rucaparib (AG-014699). (Q44226295)

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English	Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) restrict oral availability and brain accumulation of the PARP inhibitor rucaparib (AG-014699).	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

1 December 2017

Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) restrict oral availability and brain accumulation of the PARP inhibitor rucaparib (AG-014699). (English)

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Europe PubMed Central

PubMed publication ID

1 December 2017

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1 December 2017

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object named as

Jos H Beijnen

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Europe PubMed Central

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1 December 2017

author name string

Rolf W Sparidans

2

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Europe PubMed Central

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1 December 2017

Anita van Esch

3

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Europe PubMed Central

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1 December 2017

Els Wagenaar

4

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Europe PubMed Central

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1 December 2017

Alfred H Schinkel

6

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1 December 2017

publication date

25 June 2014

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1 December 2017

Pharmaceutical Research

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Europe PubMed Central

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1 December 2017

32

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1

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1 December 2017

37-46

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Europe PubMed Central

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1 December 2017

P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin

1 reference

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Poly(ADP-ribose) polymerase-1 inhibition: preclinical and clinical development of synthetic lethality

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Role of PARP inhibitors in cancer biology and therapy

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PARP inhibitors in cancer therapy: two modes of attack on the cancer cell widening the clinical applications

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Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

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Liquid chromatography-tandem mass spectrometric assay for the PARP inhibitor rucaparib in plasma.

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Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment

1 reference

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21 January 2018

Double-transduced MDCKII cells to study human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) interplay in drug transport across the blood-brain barrier

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High expression of ATP-binding cassette transporter ABCC11 in breast tumors is associated with aggressive subtypes and low disease-free survival

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain metastases from ovarian carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24962512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11095-014-1442-Z

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

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