Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3-only proteins (Q44246042)

1 December 2017

Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3-only proteins (English)

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1 December 2017

endoplasmic reticulum

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Michael J Thomenius

1

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1 December 2017

Nancy S Wang

2

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1 December 2017

Edmunds Z Reineks

3

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1 December 2017

Zhengqi Wang

4

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1 December 2017

Clark W Distelhorst

5

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1 December 2017

language of work or name

English

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publication date

10 December 2002

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Journal of Biological Chemistry

1 December 2017

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1 December 2017

278

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1 December 2017

8

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1 December 2017

6243-6250

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The Bcl-2 protein family: arbiters of cell survival

1 December 2017

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Bax directly induces release of cytochrome c from isolated mitochondria

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Conformation of the Bax C-terminus regulates subcellular location and cell death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Bax-independent inhibition of apoptosis by Bcl-XL.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208878200

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208878200

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208878200

Bim: a novel member of the Bcl-2 family that promotes apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

BH3-Only proteins-essential initiators of apoptotic cell death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Bcl-2 inhibits a Fas-induced conformational change in the Bax N terminus and Bax mitochondrial translocation.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Maintenance of calcium homeostasis in the endoplasmic reticulum by Bcl-2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208878200

Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208878200

BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208878200

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208878200

p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208878200

Transient expression of wild-type or mitochondrially targeted Bcl-2 induces apoptosis, whereas transient expression of endoplasmic reticulum-targeted Bcl-2 is protective against Bax-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208878200

Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208878200

Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208878200

Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208878200

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208878200

PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208878200

Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208878200

21 January 2018

Identifiers

DOI

10.1074/JBC.M208878200

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1 December 2017

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