ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA. (Q44267705)

1 December 2017

title

ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA. (English)

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Ulla M Wewer

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Reidar Albrechtsen

object named as

Reidar Albrechtsen

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author name string

Charles Kumar Thodeti

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1 December 2017

Meena Asmar

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1 December 2017

Christer Larsson

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1 December 2017

Arthur M Mercurio

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1 December 2017

John R Couchman

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1 December 2017

Ulla M Wewer

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1 December 2017

language of work or name

English

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publication date

31 December 2002

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Journal of Biological Chemistry

1 December 2017

published in

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1 December 2017

volume

278

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1 December 2017

issue

11

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1 December 2017

page(s)

9576-9584

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Activated R-ras, Rac1, PI 3-kinase and PKCepsilon can each restore cell spreading inhibited by isolated integrin beta1 cytoplasmic domains

1 December 2017

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RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction

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Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions

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Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization

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Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion

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The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading

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Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers

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Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4

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Syndecan-4 deficiency increases susceptibility to kappa-carrageenan-induced renal damage

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Activation of the p21 pathway of growth arrest and apoptosis by the beta 4 integrin cytoplasmic domain

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PKCalpha regulates beta1 integrin-dependent cell motility through association and control of integrin traffic

21 January 2018

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Protein kinase Cepsilon actin-binding site is important for neurite outgrowth during neuronal differentiation

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PKCepsilon, via its regulatory domain and independently of its catalytic domain, induces neurite-like processes in neuroblastoma cells

21 January 2018

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Syndecan-2 mediates adhesion and proliferation of colon carcinoma cells.

21 January 2018

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Syndecans and cell adhesion

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PKC epsilon controls the traffic of beta1 integrins in motile cells

21 January 2018

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Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement

21 January 2018

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Syndecan-4 binding to the high affinity heparin-binding domain of fibronectin drives focal adhesion formation in fibroblasts

21 January 2018

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Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy

21 January 2018

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21 January 2018

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ADAM 12 protease induces adipogenesis in transgenic mice

21 January 2018

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ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3

21 January 2018

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Disintegrin-like/cysteine-rich region of ADAM 12 is an active cell adhesion domain

21 January 2018

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Syndecan 4 heparan sulfate proteoglycan is a selectively enriched and widespread focal adhesion component

21 January 2018

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Syndecan-4 modulates focal adhesion kinase phosphorylation

21 January 2018

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Activation of Rac and Cdc42 by integrins mediates cell spreading

21 January 2018

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Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI

21 January 2018

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Changing Ligand Specificities of αvβ1 and αvβ3 Integrins by Swapping a Short Diverse Sequence of the β Subunit

21 January 2018

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Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit

21 January 2018

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ADAMs: focus on the protease domain

21 January 2018

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Syndecan-4 proteoglycan regulates the distribution and activity of protein kinase C

21 January 2018

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Syndecan-4 proteoglycan cytoplasmic domain and phosphatidylinositol 4,5-bisphosphate coordinately regulate protein kinase C activity

21 January 2018

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Syndecans-1 and -4 are induced during wound repair of neonatal but not fetal skin

21 January 2018

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Syndecan-4 up-regulation in proliferative renal disease is related to microfilament organization

21 January 2018

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Heparan sulfate proteoglycan expression in human lung-cancer cells

21 January 2018

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Dissection of Pathways Implicated in Integrin-mediated Actin Cytoskeleton Assembly

21 January 2018

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Phosphorylation of the cytoplasmic tail of syndecan-4 regulates activation of protein kinase Calpha

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208937200

21 January 2018

Identifiers

DOI

10.1074/JBC.M208937200

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1 December 2017

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