Analysis of human flap endonuclease 1 mutants reveals a mechanism to prevent triplet repeat expansion (Q44294677)

1 December 2017

Analysis of human flap endonuclease 1 mutants reveals a mechanism to prevent triplet repeat expansion (English)

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1 December 2017

Yuan Liu

1

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PubMed ID

12554738

1 December 2017

Robert A Bambara

series ordinal

2

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PubMed ID

12554738

1 December 2017

language of work or name

English

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publication date

28 January 2003

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Journal of Biological Chemistry

1 December 2017

12

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based on heuristic

inferred from page(s)

published in

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1 December 2017

278

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1 December 2017

16

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1 December 2017

13728-13739

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Differences and similarities between various tandem repeat sequences: minisatellites and microsatellites

1 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Trinucleotide repeats in neurogenetic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Simple tandem DNA repeats and human genetic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Microsatellite instability in cancer of the proximal colon

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Trinucleotide repeats that expand in human disease form hairpin structures in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Sticky DNA: self-association properties of long GAA.TTC repeats in R.R.Y triplex structures from Friedreich's ataxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Trinucleotide expansion in haploid germ cells by gap repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Molecular basis of genetic instability of triplet repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

CTG triplet repeats from human hereditary diseases are dominant genetic expansion products in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Cloned human FMR1 trinucleotide repeats exhibit a length- and orientation-dependent instability suggestive of in vivo lagging strand secondary structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Enzymatic completion of mammalian lagging-strand DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Molecular mechanism of PCNA-dependent base excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Mutations in RAD27 define a potential link between G1 cyclins and DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

The role of SOS and flap processing in microsatellite instability in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Stability of the human fragile X (CGG)(n) triplet repeat array in Saccharomyces cerevisiae deficient in aspects of DNA metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

DNA ligase I competes with FEN1 to expand repetitive DNA sequences in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

A novel role in DNA metabolism for the binding of Fen1/Rad27 to PCNA and implications for genetic risk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Novel function of Rad27 (FEN-1) in restricting short-sequence recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Flap endonuclease homologs in archaebacteria exist as independent proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Effect of flap modifications on human FEN1 cleavage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

The distribution of the numbers of mutants in bacterial populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Triplet repeats form secondary structures that escape DNA repair in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Structural analysis of slipped-strand DNA (S-DNA) formed in (CTG)n. (CAG)n repeats from the myotonic dystrophy locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

DNA ligase I and proliferating cell nuclear antigen form a functional complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

The pattern of sensitivity of yeast dna2 mutants to DNA damaging agents suggests a role in DSB and postreplication repair pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

A yeast gene required for DNA replication encodes a protein with homology to DNA helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Requirement of the yeast RTH1 5' to 3' exonuclease for the stability of simple repetitive DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

DNA mismatch repair and genetic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Removal of frameshift intermediates by mismatch repair proteins in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Gene conversion (recombination) mediates expansions of CTG[middle dot]CAG repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Repeat expansion--all in a flap?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Inhibition of flap endonuclease 1 by flap secondary structure and relevance to repeat sequence expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Human RAD2 homolog 1 5'- to 3'-exo/endonuclease can efficiently excise a displaced DNA fragment containing a 5'-terminal abasic lesion by endonuclease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Conditional lethality of null mutations in RTH1 that encodes the yeast counterpart of a mammalian 5'- to 3'-exonuclease required for lagging strand DNA synthesis in reconstituted systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

Expansions of CAG repeat tracts are frequent in a yeast mutant defective in Okazaki fragment maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

A comparison of eubacterial and archaeal structure-specific 5'-exonucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212061200

21 January 2018

Identifiers

DOI

10.1074/JBC.M212061200

1 reference

1 December 2017

1 reference

PubMed ID

12554738