Exploring new non-sugar sulfated molecules as activators of antithrombin. (Q44363642)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12639557%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

title

Exploring new non-sugar sulfated molecules as activators of antithrombin (English)

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1 November 2019

2

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1 November 2019

author name string

Gunnar T Gunnarsson

series ordinal

1

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1 November 2019

language of work or name

English

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publication date

1 February 2003

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12639557%20AND%20SRC:MED&resulttype=core&format=json

Bioorganic & Medicinal Chemistry Letters

1 November 2019

published in

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1 November 2019

volume

13

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1 November 2019

issue

4

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1 November 2019

page(s)

679-683

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An update on heparins at the beginning of the new millennium

1 November 2019

cites work

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Mechanism of heparin activation of antithrombin. Evidence for reactive center loop preinsertion with expulsion upon heparin binding

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Designing small, nonsugar activators of antithrombin using hydropathic interaction analyses.

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Synthesis of heparin fragments. A chemical synthesis of the pentasaccharide O-(2-deoxy-2-sulfamido-6-O-sulfo-alpha-D-glucopyranosyl)-(1-4 )-O-(beta-D-glucopyranosyluronic acid)-(1-4)-O-(2-deoxy-2-sulfamido-3,6-di-O-sulfo-alpha-D-glu copyranosyl)-(1-

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The region of antithrombin interacting with full-length heparin chains outside the high-affinity pentasaccharide sequence extends to Lys136 but not to Lys139.

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Critical role of the linker region between helix D and strand 2A in heparin activation of antithrombin

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Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin.

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