Signal sequence-independent membrane targeting of ribosomes containing short nascent peptides within the exit tunnel (Q44364537)

2 December 2017

Signal sequence-independent membrane targeting of ribosomes containing short nascent peptides within the exit tunnel (English)

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2 December 2017

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2 December 2017

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Wolfgang Wintermeyer

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2 December 2017

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Johannes Jöckel

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2 December 2017

Thomas Bornemann

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2 December 2017

6 April 2008

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Nature Structural & Molecular Biology

2 December 2017

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2 December 2017

15

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2 December 2017

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2 December 2017

494-499

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https://scigraph.springernature.com/pub.10.1038/nsmb.1402

2 December 2017

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cites work

In vitro studies with purified components reveal signal recognition particle (SRP) and SecA/SecB as constituents of two independent protein-targeting pathways of Escherichia coli

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The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins

21 January 2018

1 reference

The functional integration of a polytopic membrane protein of Escherichia coli is dependent on the bacterial signal-recognition particle.

21 January 2018

1 reference

Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthens.

21 January 2018

1 reference

X-ray structure of a protein-conducting channel

21 January 2018

1 reference

Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes

21 January 2018

1 reference

Signal recognition particle mediates a transient elongation arrest of preprolactin in reticulocyte lysate

21 January 2018

1 reference

Elongation arrest is a physiologically important function of signal recognition particle

21 January 2018

1 reference

Targeting and insertion of heterologous membrane proteins in E. coli

21 January 2018

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Assembly of a cytoplasmic membrane protein in Escherichia coli is dependent on the signal recognition particle.

21 January 2018

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HemK, a class of protein methyl transferase with similarity to DNA methyl transferases, methylates polypeptide chain release factors, and hemK knockout induces defects in translational termination

21 January 2018

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Domain rearrangement of SRP protein Ffh upon binding 4.5S RNA and the SRP receptor FtsY

21 January 2018

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Conformations of the signal recognition particle protein Ffh from Escherichia coli as determined by FRET.

21 January 2018

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Crystal structure of the ribonucleoprotein core of the signal recognition particle

21 January 2018

1 reference

The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

21 January 2018

1 reference

Early encounters of a nascent membrane protein: specificity and timing of contacts inside and outside the ribosome.

21 January 2018

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Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins.

21 January 2018

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Folding zones inside the ribosomal exit tunnel

21 January 2018

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Systematic introduction of proline in a eukaryotic signal sequence suggests asymmetry within the hydrophobic core

21 January 2018

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Recognition of transmembrane helices by the endoplasmic reticulum translocon.

21 January 2018

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Export of beta-lactamase is independent of the signal recognition particle.

21 January 2018

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The core Escherichia coli signal recognition particle receptor contains only the N and G domains of FtsY

21 January 2018

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Important role of the tetraloop region of 4.5S RNA in SRP binding to its receptor FtsY.

21 January 2018

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Role of 4.5S RNA in assembly of the bacterial signal recognition particle with its receptor

21 January 2018

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Structure of the signal recognition particle interacting with the elongation-arrested ribosome.

21 January 2018

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The signal recognition particle binds to protein L23 at the peptide exit of the Escherichia coli ribosome

21 January 2018

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L23 protein functions as a chaperone docking site on the ribosome

21 January 2018

1 reference

Association of protein biogenesis factors at the yeast ribosomal tunnel exit is affected by the translational status and nascent polypeptide sequence

21 January 2018

1 reference

Interaction of E. coli Ffh/4.5S ribonucleoprotein and FtsY mimics that of mammalian signal recognition particle and its receptor.

21 January 2018

1 reference

Domain interactions in E. coli SRP: stabilization of M domain by RNA is required for effective signal sequence modulation of NG domain.

21 January 2018

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The ribosomal exit tunnel functions as a discriminating gate

21 January 2018

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Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements

21 January 2018

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Changes produced by bound tryptophan in the ribosome peptidyl transferase center in response to TnaC, a nascent leader peptide

21 January 2018

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Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on the Escherichia coli ribosome

21 January 2018

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Cloning and sequence analysis of the Escherichia coli 4.5 S RNA gene

21 January 2018

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Physical nature of bacterial cytoplasm.

21 January 2018

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Conformational changes in the bacterial SRP receptor FtsY upon binding of guanine nucleotides and SRP.

21 January 2018

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Optimal posttranslational translocation of the precursor of PhoE protein across Escherichia coli membrane vesicles requires both ATP and the protonmotive force.

21 January 2018

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In vitro translocation of bacterial proteins across the plasma membrane of Escherichia coli

21 January 2018

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GTP consumption of elongation factor Tu during translation of heteropolymeric mRNAs

21 January 2018

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Conformation of 4.5S RNA in the signal recognition particle and on the 30S ribosomal subunit

21 January 2018

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BIOGENESIS OF INNER MEMBRANE PROTEINS IN ESCHERICHIA COLI

21 January 2018

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Fast events in protein folding: the time evolution of primary processes

21 January 2018

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Both lumenal and cytosolic gating of the aqueous ER translocon pore are regulated from inside the ribosome during membrane protein integration

31 March 2020

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Concentrations of 4.5S RNA and Ffh protein in Escherichia coli: the stability of Ffh protein is dependent on the concentration of 4.5S RNA.

31 March 2020

1 reference

Quantitative Film Detection of 3H and 14C in Polyacrylamide Gels by Fluorography

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NSMB.1402

1 reference

2 December 2017

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PubMed ID

18391966