Vitamin C protects low-density lipoprotein from homocysteine-mediated oxidation (Q44374153)

2 December 2017

title

Vitamin C protects low-density lipoprotein from homocysteine-mediated oxidation (English)

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2 December 2017

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Rushdi H Alul

1

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2 December 2017

Michael Wood

2

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2 December 2017

Joseph Longo

3

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2 December 2017

Anthony L Marcotte

4

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2 December 2017

Allan L Campione

5

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2 December 2017

Michael K Moore

6

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2 December 2017

Sean M Lynch

7

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2 December 2017

language of work or name

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1 April 2003

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Free Radical Biology and Medicine

2 December 2017

published in

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2 December 2017

volume

34

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2 December 2017

issue

7

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2 December 2017

page(s)

881-891

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The role of oxidized lipoproteins in atherogenesis

2 December 2017

cites work

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https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Homocysteine and cardiovascular disease

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https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Homocysteine induces iron-catalyzed lipid peroxidation of low-density lipoprotein that is prevented by alpha-tocopherol

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Physiological thiol compounds exert pro- and anti-oxidant effects, respectively, on iron- and copper-dependent oxidation of human low-density lipoprotein

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https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo

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https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Enhanced in vivo lipid peroxidation at elevated plasma total homocysteine levels.

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7 January 2021

Relationship between homocysteine and superoxide dismutase in homocystinuria: possible relevance to cardiovascular risk

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https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Lowering of body iron stores by blood letting and oxidation resistance of serum lipoproteins: a randomized cross-over trial in male smokers.

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7 January 2021

Donation of Blood Is Associated with Reduced Risk of Myocardial Infarction: The Kuopio Ischaemic Heart Disease Risk Factor Study

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7 January 2021

Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular death in women

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7 January 2021

Increased Risk of Acute Myocardial Infarction in Carriers of the Hemochromatosis Gene Cys282Tyr Mutation

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7 January 2021

Iron chelation improves endothelial function in patients with coronary artery disease.

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https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

17 beta-estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Exposure to oxidized low-density lipoprotein in vivo enhances intimal thickening and selectively impairs endothelium-dependent dilation in the rabbit

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Co-incubation of native and oxidized low-density lipoproteins: potentiation of relaxation impairment

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Endothelial dysfunction induced by oxidized low-density lipoproteins in isolated mouse aorta: a comparison with apolipoprotein-E deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Ascorbate is an outstanding antioxidant in human blood plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Single vertical spin density gradient ultracentrifugation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Plasma thiols inhibit hemin-dependent oxidation of human low-density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Reduction of copper, but not iron, by human low density lipoprotein (LDL). Implications for metal ion-dependent oxidative modification of LDL

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Tissue sulfhydryl groups

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Simultaneous determination of two antioxidants, uric and ascorbic acid, in animal tissue by high-performance liquid chromatography

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Measurement of antioxidants in human blood plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Evaluation of an isoluminol chemiluminescence assay for the detection of hydroperoxides in human blood plasma.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Assay of lipid hydroperoxides using high-performance liquid chromatography with isoluminal chemiluminescence detection

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

The role of lipid peroxidation and antioxidants in oxidative modification of LDL.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Antioxidant defenses and lipid peroxidation in human blood plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Vitamin C prevents metal ion-dependent initiation and propagation of lipid peroxidation in human low-density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Vitamin C protects against and reverses specific hypochlorous acid- and chloramine-dependent modifications of low-density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Both intracellular and extracellular vitamin C inhibit atherogenic modification of LDL by human vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Physiological increments in plasma homocysteine induce vascular endothelial dysfunction in normal human subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

The effects of oral methionine and homocysteine on endothelial function

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Investigation of relationship between reduced, oxidized, and protein-bound homocysteine and vascular endothelial function in healthy human subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Redox cycling of iron and lipid peroxidation.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Deleterious iron-mediated oxidation of biomolecules

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Copper-catalyzed autoxidations of GSH and L-ascorbic acid: mutual inhibition of the respective oxidations by their coexistence

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Coantioxidants make alpha-tocopherol an efficient antioxidant for low-density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Formation of non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Copper ions promote peroxidation of low density lipoprotein lipid by binding to histidine residues of apolipoprotein B100, but they are reduced at other sites on LDL

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

The effect of histidine modification on copper-dependent lipid peroxidation in human low-density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Inhibition of copper-induced LDL oxidation by vitamin C is associated with decreased copper-binding to LDL and 2-oxo-histidine formation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Measurement of copper-binding sites on low density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Mechanisms of metal ion-dependent oxidation of human low density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Selective resistance of LDL core lipids to iron-mediated oxidation. Implications for the biological properties of iron-oxidized LDL.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

2-Oxo-histidine as a novel biological marker for oxidatively modified proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Reduction of dehydroascorbic acid by homocysteine

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Analysis of the transformation products of dehydro-L-ascorbic acid by ion-pairing high-performance liquid chromatography

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Spontaneous conversion of L-dehydroascorbic acid to L-ascorbic acid and L-erythroascorbic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Vitamin C: antioxidant or pro-oxidant in vivo?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Vitamin C: poison, prophylactic or panacea?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Iron-induced ascorbate oxidation in plasma as monitored by ascorbate free radical formation. No spin-trapping evidence for the hydroxyl radical in iron-overloaded plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Antioxidant activity of vitamin C in iron-overloaded human plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Effects of co-supplementation of iron with ascorbic acid on antioxidant--pro-oxidant balance in the guinea pig.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Vitamin C suppresses oxidative lipid damage in vivo, even in the presence of iron overload

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Biochemical markers related to Alzheimer's dementia in serum and cerebrospinal fluid

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Increased CSF F2-isoprostane concentration in probable AD.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Time-course of oxidation of lipids in human cerebrospinal fluid in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

Increased lipoprotein oxidation in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

The effect of ascorbate and ubiquinone supplementation on plasma and CSF total antioxidant capacity.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2803%2900028-5

7 January 2021

10.1016/S0891-5849(03)00028-5

Identifiers

DOI

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2 December 2017

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