The molecular chaperone Cosmc enhances malignant behaviors of colon cancer cells via activation of Akt and ERK. (Q44392892)

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23 February 2020

title

The molecular chaperone Cosmc enhances malignant behaviors of colon cancer cells via activation of Akt and ERK (English)

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23 February 2020

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8

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23 February 2020

Jin-Tung Liang

9

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23 February 2020

Ji-Shiang Hung

4

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23 February 2020

author name string

John Huang

1

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23 February 2020

Mei-Ieng Che

2

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23 February 2020

Neng-Yu Lin

3

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23 February 2020

Yu-Ting Huang

5

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23 February 2020

Wei-Chou Lin

6

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Hsiu-Chin Huang

7

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Min-Chuan Huang

10

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publication date

6 February 2013

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23 February 2020

published in

Molecular Carcinogenesis

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23 February 2020

volume

53 Suppl 1

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page(s)

E62-71

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The sweet and sour of cancer: glycans as novel therapeutic targets

23 February 2020

cites work

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Targeted disruption of the gene encoding core 1 beta1-3-galactosyltransferase (T-synthase) causes embryonic lethality and defective angiogenesis in mice

21 January 2018

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Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion.

21 January 2018

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Immunoreactive T and Tn epitopes in cancer diagnosis, prognosis, and immunotherapy

21 January 2018

1 reference

A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase

21 January 2018

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Cosmc is an essential chaperone for correct protein O-glycosylation

21 January 2018

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Protein glycosylation: chaperone mutation in Tn syndrome

21 January 2018

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New mutations in C1GALT1C1 in individuals with Tn positive phenotype

21 January 2018

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A mutant chaperone converts a wild-type protein into a tumor-specific antigen

21 January 2018

1 reference

Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3

21 January 2018

1 reference

Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL.

21 January 2018

1 reference

Expression of sialyl-Tn epitopes on beta1 integrin alters epithelial cell phenotype, proliferation and haptotaxis.

21 January 2018

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O-glycosylation regulates autolysis of cellular membrane type-1 matrix metalloproteinase (MT1-MMP).

21 January 2018

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The alpha (1,3)-fucosyltransferase Fuc-TIV, but not Fuc-TVII, generates sialyl Lewis X-like epitopes preferentially on glycolipids

21 January 2018

1 reference

Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for insulin-stimulated production of nitric oxide in endothelial cells

21 January 2018

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Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK

21 January 2018

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C2GnT-M is downregulated in colorectal cancer and its re-expression causes growth inhibition of colon cancer cells.

21 January 2018

1 reference

Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc

21 January 2018

1 reference

Absence of COSMC gene mutations in breast and colorectal carcinomas.

21 January 2018

1 reference

Mucin-type O-glycosylation and its potential use in drug and vaccine development

21 January 2018

1 reference

Mucin-type O-glycans in human colon and breast cancer: glycodynamics and functions

21 January 2018

1 reference

The Tn antigen-structural simplicity and biological complexity

21 January 2018

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Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells.

21 January 2018

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Regulation of protein O-glycosylation by the endoplasmic reticulum-localized molecular chaperone Cosmc

21 January 2018

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Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice

21 January 2018

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Polypeptide N-acetylgalactosaminyltransferase 6 disrupts mammary acinar morphogenesis through O-glycosylation of fibronectin

21 January 2018

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Critical roles of mucin 1 glycosylation by transactivated polypeptide N-acetylgalactosaminyltransferase 6 in mammary carcinogenesis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MC.22011

1 reference

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23 February 2020

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