IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells (Q44394226)

2 December 2017

IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells (English)

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2 December 2017

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2

Forest Rohwer

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2 December 2017

Michelle M Fung

1

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PubMed ID

12681450

2 December 2017

Kathleen L McGuire

series ordinal

3

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2 December 2017

1 June 2003

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2 December 2017

12

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inferred from page(s)

published in

Cellular Signalling

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2 December 2017

15

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2 December 2017

6

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2 December 2017

625-636

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Interleukin-2: inception, impact, and implications

2 December 2017

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7 January 2021

Biology of the interleukin-2 receptor

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7 January 2021

Functional dissection of the cytoplasmic subregions of the IL-2 receptor betac chain in primary lymphocyte populations

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https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

IL-2 signaling: recruitment and activation of multiple protein tyrosine kinases by the components of the IL-2 receptor

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https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Activation and signal transduction via mitogen-activated protein (MAP) kinases in T lymphocytes

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https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Interaction of Shc with Grb2 regulates the Grb2 association with mSOS

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7 January 2021

Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line

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https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Interleukin 2 activates extracellular signal-regulated protein kinase 2.

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https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro

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https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

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https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Ras regulation and function in lymphocytes.

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https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15

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https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

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https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

STAT3 is a serine kinase target in T lymphocytes. Interleukin 2 and T cell antigen receptor signals converge upon serine 727.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Two Discrete Regions of Interleukin-2 (IL2) Receptor β Independently Mediate IL2 Activation of a PD98059/Rapamycin/Wortmannin-insensitive Stat5a/b Serine Kinase

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https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

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https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

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https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Phosphatidylinositol 3-kinase potentiates, but does not trigger, T cell proliferation mediated by the IL-2 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway

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https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

IL-2 and IL-7 induce heterodimerization of STAT5 isoforms in human peripheral blood T lymphoblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Cytokine-mediated inhibition of apoptosis in non-transformed T cells and neutrophils can be dissociated from protein kinase B activation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Requirement of serine phosphorylation for formation of STAT-promoter complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5.

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https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

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https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900003-2

7 January 2021

10.1016/S0898-6568(03)00003-2

Identifiers

DOI

1 reference

2 December 2017

1 reference

PubMed ID

12681450