Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells. (Q44399844)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20568240%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells (English)

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6 February 2020

0 references

1

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6 February 2020

Yu Wang

3

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6 February 2020

author name string

Yong Yang

2

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6 February 2020

Aimin Xu

4

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6 February 2020

Donghai Wu

5

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6 February 2020

Yonglong Chen

6

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6 February 2020

publication date

1 August 2010

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6 February 2020

published in

Developmental Dynamics

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6 February 2020

volume

239

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6 February 2020

issue

8

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6 February 2020

page(s)

2198-2207

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Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells

6 February 2020

cites work

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Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression

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Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice.

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Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus

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Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells.

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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XsFRP5 modulates endodermal organogenesis in Xenopus laevis.

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Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development.

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Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

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Regulation of pancreas plasticity and malignant transformation by Akt signaling.

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A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway

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7 January 2021

Appendix G: In Situ Hybridization: An Improved Whole-Mount Method for Xenopus Embryos

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7 January 2021

Programmed cell death during Xenopus development: a spatio-temporal analysis

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7 January 2021

Expression of amylase and other pancreatic genes in Xenopus.

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7 January 2021

Experimental conversion of liver to pancreas

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7 January 2021

Xenopus insm1 is essential for gastrointestinal and pancreatic endocrine cell development

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Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas

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7 January 2021

The tetraspanin Tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds

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7 January 2021

Development of the pancreas in Xenopus laevis

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7 January 2021

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

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7 January 2021

Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling

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7 January 2021

APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction

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7 January 2021

Mediation of the DCC apoptotic signal by DIP13 alpha

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7 January 2021

AKT/PKB signaling: navigating downstream

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7 January 2021

APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function

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7 January 2021

Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development

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7 January 2021

Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

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7 January 2021

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

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7 January 2021

Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

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7 January 2021

Pancreas and beta-cell development: from the actual to the possible

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7 January 2021

Beta-catenin is essential for pancreatic acinar but not islet development

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7 January 2021

Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling

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7 January 2021

APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex

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7 January 2021

The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number

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7 January 2021

Retinoic acid-mediated patterning of the pre-pancreatic endoderm in Xenopus operates via direct and indirect mechanisms.

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7 January 2021

Xenopus pancreas development

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7 January 2021

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription

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7 January 2021

Non-cell-autonomous retinoid signaling is crucial for renal development

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7 January 2021

The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation

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7 January 2021

The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development

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7 January 2021

The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm.

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7 January 2021

Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts

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7 January 2021

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

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7 January 2021

Wnt/beta-catenin signaling is required for development of the exocrine pancreas

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7 January 2021

Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways

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