Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro (Q44403620)

2 December 2017

Utility of hepatocytes in predicting drug metabolism: comparison of hepatic intrinsic clearance in rats and humans in vivo and in vitro (English)

1 reference

https://api.crossref.org/works/10.1124/DMD.31.5.580

2 December 2017

Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro (English)

1 reference

https://api.crossref.org/works/10.1124/DMD.31.5.580

24 December 2023

main subject

pharmaceutical science

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24 December 2023

1 reference

https://api.crossref.org/works/10.1124/DMD.31.5.580

24 December 2023

author name string

Yoichi Naritomi

1

1 reference

2 December 2017

Shigeyuki Terashita

2

1 reference

2 December 2017

Akira Kagayama

3

1 reference

2 December 2017

Yuichi Sugiyama

4

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2 December 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12695346

reference URL

24 December 2023

publication date

1 May 2003

1 reference

full work available at URL

2 December 2017

https://syndication.highwire.org/content/doi/10.1124/dmd.31.5.580

1 reference

https://api.crossref.org/works/10.1124/DMD.31.5.580

Drug Metabolism and Disposition

24 December 2023

published in

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2 December 2017

31

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2 December 2017

5

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2 December 2017

580-588

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Prediction of in vivo disposition from in vitro systems: clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data.

2 December 2017

https://api.crossref.org/works/10.1124/DMD.31.5.580

1

1 reference

Utility of hepatocytes to model species differences in the metabolism of loxtidine and to predict pharmacokinetic parameters in rat, dog and man

24 December 2023

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2

1 reference

Viability and function in primary culture of adult hepatocytes from various animal species and human beings after cryopreservation.

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

5

1 reference

Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

6

1 reference

Clinical pharmacokinetics of zidovudine. An overview of current data

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

7

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Cryopreservation of human adult hepatocytes for use in drug metabolism and toxicity studies

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

8

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Physiological parameters in laboratory animals and humans

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

9

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Tissue distribution and metabolic disposition of zidovudine in rats.

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

10

1 reference

Pharmacokinetics of diazepam in the rat: influence of a carbon tetrachloride-induced hepatic injury

24 December 2023

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11

1 reference

The binding of paracetamol to plasma proteins of man and pig

24 December 2023

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12

1 reference

Probenecid inhibits the metabolic and renal clearances of zidovudine (AZT) in human volunteers

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

13

1 reference

Predicting the hepatic clearance of xenobiotics in humans from in vitro data

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

16

1 reference

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

17

1 reference

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

18

1 reference

Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

19

1 reference

Prediction of the human pharmacokinetics of troglitazone, a new and extensively metabolized antidiabetic agent, after oral administration, with an animal scale-up approach.

24 December 2023

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20

1 reference

Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat

24 December 2023

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23

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Pharmacokinetic model of diltiazem.

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

24

1 reference

Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

26

1 reference

Decreased systemic clearance of diltiazem with increased hepatic metabolism in rats with uranyl nitrate-induced acute renal failure

24 December 2023

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27

1 reference

Estimation of oral drug absorption in man based on intestine permeability in rats

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

28

1 reference

Survival and function of isolated hepatocytes after cryopreservation

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

29

1 reference

Effect of prevention of inorganic sulfate depletion on the pharmacokinetics of acetaminophen in rats.

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

30

1 reference

Kinetic studies on the deethylation of ethoxybenzamide. A comparative study with isolated hepatocytes and liver microsomes of rat

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

31

1 reference

Interaction between erythromycin and the benzodiazepines diazepam and flunitrazepam.

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

32

1 reference

Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

35

1 reference

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

37

1 reference

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

38

1 reference

Pharmacokinetics of diltiazem in selected animal species and human beings

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

39

1 reference

Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

40

1 reference

Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

42

1 reference

Therapeutic doses of codeine have no effect on acetaminophen clearance or metabolism

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

43

1 reference

Metabolic activity of fresh and cryopreserved dog hepatocyte suspensions.

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

45

1 reference

Biochemical studies on liver functions in primary cultured hepatocytes of adult rats. I. Hormonal effects on cell viability and protein synthesis

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

46

1 reference

Pharmacokinetics and metabolism of diltiazem in rats following a single intra-arterial or single oral dose

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

48

1 reference

Correlating partitioning and caco-2 cell permeability of structurally diverse small molecular weight compounds

24 December 2023

https://api.crossref.org/works/10.1124/DMD.31.5.580

50

1 reference

24 December 2023

Identifiers

DOI

10.1124/DMD.31.5.580

1 reference

2 December 2017

1 reference