The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition (Q44406747)

2 December 2017

title

The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition (English)

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2 December 2017

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8

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2 December 2017

Xiao-Feng Le

1

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2 December 2017

Francois-Xavier Claret

2

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2 December 2017

Amy Lammayot

3

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2 December 2017

Ling Tian

4

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2 December 2017

Deepa Deshpande

5

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2 December 2017

Ruth LaPushin

6

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2 December 2017

Ana M Tari

7

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2 December 2017

language of work or name

English

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publication date

16 April 2003

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Journal of Biological Chemistry

2 December 2017

published in

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2 December 2017

volume

278

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2 December 2017

issue

26

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2 December 2017

page(s)

23441-23450

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Molecular mechanisms underlying ErbB2/HER2 action in breast cancer

2 December 2017

cites work

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Translational control of p27Kip1 accumulation during the cell cycle

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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

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Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

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Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

21 January 2018

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A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

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Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

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Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1

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PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1

21 January 2018

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

21 January 2018

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

21 January 2018

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Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells

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ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency

21 January 2018

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The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells

21 January 2018

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Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C alpha activity

21 January 2018

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In vitro and in vivo anti-tumour effects of a humanised monoclonal antibody against c-erbB-2 product

21 January 2018

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Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest

21 January 2018

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

21 January 2018

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

21 January 2018

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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

21 January 2018

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Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M300848200

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2 December 2017

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