Allelic Exclusion of the TCR α-Chain Is an Active Process Requiring TCR-Mediated Signaling and c-Cbl (Q44411468)

2 December 2017

title

Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl (English)

1 reference

2 December 2017

Allelic Exclusion of the TCR α-Chain Is an Active Process Requiring TCR-Mediated Signaling and c-Cbl (English)

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.170.9.4557

26 December 2023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12707333

26 December 2023

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.170.9.4557

26 December 2023

author

Nicholas R J Gascoigne

7

object named as

Nicholas R J Gascoigne

1 reference

2 December 2017

5

Mayumi Naramura

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12707333

26 December 2023

author name string

Nathalie Niederberger

1

1 reference

2 December 2017

Kaisa Holmberg

2

1 reference

2 December 2017

Wayne Sakati

4

1 reference

2 December 2017

Hua Gu

6

1 reference

2 December 2017

S. Munir Alam

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12707333

26 December 2023

language of work or name

English

0 references

publication date

1 May 2003

1 reference

full work available at URL

2 December 2017

published in

Journal of Immunology

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2 December 2017

volume

170

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2 December 2017

issue

9

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2 December 2017

page(s)

4557-4563

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Regulation of TCR alpha and beta gene allelic exclusion during T-cell development

2 December 2017

cites work

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Allelic exclusion of the T cell receptor alpha-chain: developmental regulation of a post-translational event

26 December 2023

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In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes

26 December 2023

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Exclusion and inclusion of α and β T cell receptor alleles

26 December 2023

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Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression

26 December 2023

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The influence of positive selection on RAG expression in thymocytes

26 December 2023

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Each of the two productive T cell receptor alpha-gene rearrangements found in both the A10 and BM 3.3 T cell clones give rise to an alpha chain which can contribute to the constitution of a surface-expressed alpha beta dimer.

26 December 2023

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Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers

26 December 2023

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Allelic exclusion of mouse T cell receptor α chains occurs at the time of thymocyte TCR up-regulation

26 December 2023

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The T cell antigen receptor: insights into organelle biology

26 December 2023

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On the dynamics of TCR:CD3 complex cell surface expression and downmodulation

26 December 2023

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Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck

26 December 2023

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Protein tyrosine kinase p56 lck controls allelic exclusion of T-cell receptor β-chain genes

26 December 2023

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Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation

26 December 2023

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Integration of T cell receptor-dependent signaling pathways by adapter proteins

26 December 2023

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The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation

26 December 2023

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The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells

26 December 2023

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Altered thymic positive selection and intracellular signals in Cbl-deficient mice

26 December 2023

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Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

26 December 2023

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The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha

26 December 2023

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

26 December 2023

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Ubiquitin and the control of protein fate in the secretory and endocytic pathways

26 December 2023

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Activation-induced ubiquitination of the T cell antigen receptor

26 December 2023

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T cell antigen receptor ubiquitination is a consequence of receptor-mediated tyrosine kinase activation

26 December 2023

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c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

26 December 2023

28

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Receptor engagement transiently diverts the T cell receptor heterodimer from a constitutive degradation pathway.

26 December 2023

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Triggering the TCR Complex Causes the Downregulation of Nonengaged Receptors by a Signal Transduction-Dependent Mechanism

26 December 2023

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Identification of a naturally occurring ligand for thymic positive selection

26 December 2023

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Phenotypic differences between alpha beta versus beta T-cell receptor transgenic mice undergoing negative selection

26 December 2023

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Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse

26 December 2023

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T-cell-receptor affinity and thymocyte positive selection

26 December 2023

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T cell positive selection by a high density, low affinity ligand

26 December 2023

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Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells.

26 December 2023

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Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and

26 December 2023

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Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

26 December 2023

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Role of TCR zeta chain in T cell development and selection

26 December 2023

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T cell receptor antagonist peptides induce positive selection

26 December 2023

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Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction

26 December 2023

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Identification of the homologous beige and Chediak-Higashi syndrome genes

26 December 2023

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A T cell clone expresses two T cell receptor alpha genes but uses one alpha beta heterodimer for allorecognition and self MHC-restricted antigen recognition

26 December 2023

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26 December 2023

Identifiers

1 reference

2 December 2017

1 reference