R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization. (Q44414360)

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scientific article published on 2 July 2007

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English	R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization.	scientific article published on 2 July 2007

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scholarly article

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1 January 2020

R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization (English)

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G protein-coupled receptor

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Mohammed Akhter Hossain

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Chester Kuei

1

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Pascal Bonaventure

3

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Cindy Pudiak

4

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Jonathan Shelton

5

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Jessica Zhu

6

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Diane Nepomuceno

7

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Jiejun Wu

8

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Jingcai Chen

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Fredrik Kamme

10

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Mark Seierstad

11

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Michael D Hack

12

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Timothy W Lovenberg

17

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Changlu Liu

18

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publication date

2 July 2007

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Journal of Biological Chemistry

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282

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35

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25425-25435

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1 January 2020

Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Identification of Relaxin-3/INSL7 as an Endogenous Ligand for the Orphan G-protein-coupled Receptor GPCR135

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Distribution of G-protein-coupled receptor (GPCR)135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

G-protein-coupled receptor (GPCR)-142 does not contribute to relaxin-3 binding in the mouse brain: further support that relaxin-3 is the physiological ligand for GPCR135.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond to stress.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Central relaxin-3 administration causes hyperphagia in male Wistar rats.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Chronic intracerebroventricular administration of relaxin-3 increases body weight in rats

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Identification of Relaxin-3/INSL7 as a Ligand for GPCR142

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Identification of INSL5, a new member of the insulin superfamily

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Pharmacological characterization of relaxin-3/INSL7 receptors GPCR135 and GPCR142 from different mammalian species.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

The Three Subfamilies of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors (LGR): Identification of LGR6 and LGR7 and the Signaling Mechanism for LGR7

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Activation of orphan receptors by the hormone relaxin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Impaired nipple development and parturition in LGR7 knockout mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Relaxin-induced reduction of infarct size in male rats receiving MCAO is dependent on nitric oxide synthesis and not estrogenic mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Relaxin in vascular physiology and pathophysiology: possible implications in ischemic brain disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Relaxin's physiological roles and other diverse actions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Structure of a genomic clone encoding biologically active human relaxin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Interactions of phenol and m-cresol in the insulin hexamer, and their effect on the association properties of B28 pro --> Asp insulin analogues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Molecular characterization and in vitro biological activity of placentin, a new member of the insulin gene family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Characterization of the mouse and rat relaxin receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Identification of a mouse orthologue of the G-protein-coupled receptor SALPR and its expression in adult mouse brain and during development.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Connections of the nucleus incertus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

Relaxin-3: Improved Synthesis Strategy and Demonstration of Its High-Affinity Interaction with the Relaxin Receptor LGR7 BothIn VitroandIn Vivo†

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701416200

21 January 2018

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