New roles for TIM family members in immune regulation (Q44470505)

3 December 2017

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title

New roles for TIM family members in immune regulation (English)

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3 December 2017

Vijay K Kuchroo

1

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3 December 2017

Valerie Dardalhon

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2

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3 December 2017

Sheng Xiao

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3

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3 December 2017

Ana C Anderson

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4

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3 December 2017

1 August 2008

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Nature Reviews Immunology

3 December 2017

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3 December 2017

8

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3 December 2017

577-580

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3 December 2017

8

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Cutting edge: inhibition of T cell activation by TIM-2.

3 December 2017

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TIM-4 expressed on APCs induces T cell expansion and survival

21 January 2018

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T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis

21 January 2018

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Lack of TIM-3 immunoregulation in multiple sclerosis

21 January 2018

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The TIM gene family: emerging roles in immunity and disease

21 January 2018

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TIM-1 induces T cell activation and inhibits the development of peripheral tolerance

31 March 2020

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TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation.

31 March 2020

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Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17

31 March 2020

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Epitope-dependent effect of anti-murine TIM-1 monoclonal antibodies on T cell activity and lung immune responses

31 March 2020

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T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation

31 March 2020

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Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice

31 March 2020

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Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function

31 March 2020

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The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model

31 March 2020

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Human TIM-1 associates with the TCR complex and up-regulates T cell activation signals

31 March 2020

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Tim-2 regulates T helper type 2 responses and autoimmunity

31 March 2020

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Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2.

31 March 2020

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Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice

31 March 2020

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T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation

31 March 2020

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Bimodal regulation of T cell-mediated immune responses by TIM-4

31 March 2020

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Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

31 March 2020

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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

31 March 2020

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Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells

31 March 2020

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T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface

31 March 2020

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Structures of T Cell immunoglobulin mucin receptors 1 and 2 reveal mechanisms for regulation of immune responses by the TIM receptor family

31 March 2020

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Structures of T Cell Immunoglobulin Mucin Protein 4 Show a Metal-Ion-Dependent Ligand Binding Site where Phosphatidylserine Binds

31 March 2020

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Identification of Tim4 as a phosphatidylserine receptor

31 March 2020

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TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.

31 March 2020

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Dysregulated T cell expression of TIM3 in multiple sclerosis

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2366

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3 December 2017

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