In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine). (Q44523578)

3 December 2017

title

In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine). (English)

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3 December 2017

Jeffery J Anderson

1

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3 December 2017

Margaret J Bradbury

2

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3 December 2017

Darlene R Giracello

3

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3 December 2017

Deborah F Chapman

4

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3 December 2017

Greg Holtz

5

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3 December 2017

Jeffrey Roppe

6

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3 December 2017

Chris King

7

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3 December 2017

Nicholas D P Cosford

8

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3 December 2017

Mark A Varney

9

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3 December 2017

language of work or name

English

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publication date

1 July 2003

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European Journal of Pharmacology

3 December 2017

published in

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3 December 2017

volume

473

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3 December 2017

issue

1

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3 December 2017

page(s)

35-40

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[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization

3 December 2017

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Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors.

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Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone

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Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893).

7 January 2021

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Pharmacology and functions of metabotropic glutamate receptors

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[3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

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[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5.

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Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP

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In vitro characterization of [3H]MethoxyPyEP, an mGluR5 selective radioligand

7 January 2021

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Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain

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Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

7 January 2021

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Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain.

7 January 2021

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10.1016/S0014-2999(03)01935-6

7 January 2021

Identifiers

DOI

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3 December 2017

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