Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR. (Q44550541)

4 December 2017

Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR. (English)

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4 December 2017

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4 December 2017

Michelle M Tabb

1

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4 December 2017

Aixu Sun

2

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4 December 2017

Felix Grün

4

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4 December 2017

Jody Errandi

5

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4 December 2017

Kimberly Romero

6

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4 December 2017

Hang Pham

7

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4 December 2017

Satoshi Inoue

8

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4 December 2017

Shyamali Mallick

9

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4 December 2017

Min Lin

10

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4 December 2017

Barry M Forman

11

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4 December 2017

Bruce Blumberg

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4 December 2017

language of work or name

English

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publication date

14 August 2003

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Journal of Biological Chemistry

4 December 2017

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4 December 2017

278

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4 December 2017

45

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4 December 2017

43919-43927

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Vitamin K2 modulates proliferation and function of osteoblastic cells in vitro

4 December 2017

1 reference

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Maternal and fetal sequelae of anticoagulation during pregnancy

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The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain.

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Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis

21 January 2018

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A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-progestin therapy

21 January 2018

1 reference

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Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis

21 January 2018

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Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk

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21 January 2018

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Vitamin K-dependent carboxylase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303136200

Role of vitamin K in bone metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303136200

BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites.

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

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Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR.

21 January 2018

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

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The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

21 January 2018

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PXR, CAR and drug metabolism

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303136200

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303136200

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303136200

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303136200

St John's wort, a herbal antidepressant, activates the steroid X receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303136200

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303136200

Benzoate X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303136200

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

21 January 2018

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Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303136200

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303136200

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

1 reference

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Target cells in bone for parathormone and calcitonin are different: enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces

21 January 2018

1 reference

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Orphan nuclear receptors: the exotics of xenobiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303136200

Quantitative analysis of constitutive and inducible CYPs mRNA expression in the HepG2 cell line using reverse transcription-competitive PCR.

21 January 2018

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Vitamin D receptor as an intestinal bile acid sensor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303136200

Sequence elements in the human osteocalcin gene confer basal activation and inducible response to hormonal vitamin D3.

21 January 2018

1 reference

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Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression

21 January 2018

1 reference

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1,25-Dihydroxyvitamin D3 regulates the biosynthesis of osteopontin, a bone-derived cell attachment protein, in clonal osteoblast-like osteosarcoma cells

21 January 2018

1 reference

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Necessity of enzymatic activity of alkaline phosphatase for mineralization of osteoblastic cells

21 January 2018

1 reference

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Regulation of alkaline phosphatase and alpha 2(I) procollagen synthesis during early intramembranous bone formation in the rat mandible

21 January 2018

1 reference

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Biochemical markers for the detection of bone metastasis in patients with prostate cancer: diagnostic efficacy and the effect of hormonal therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303136200

Osteopontin--a possible anchor of osteoclasts to bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303136200

cDNA cloning, mRNA distribution and heterogeneity, chromosomal location, and RFLP analysis of human osteopontin (OPN)

21 January 2018

1 reference

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Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein

21 January 2018

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Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves

21 January 2018

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Induction of matrix Gla protein synthesis during prolonged 1,25-dihydroxyvitamin D3 treatment of osteosarcoma cells

21 January 2018

1 reference

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Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

21 January 2018

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Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis

21 January 2018

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Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro

21 January 2018

1 reference

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Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines

21 January 2018

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21 January 2018

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Effect of vitamin K2 on osteoblast apoptosis: vitamin K2 inhibits apoptotic cell death of human osteoblasts induced by Fas, proteasome inhibitor, etoposide, and staurosporine

21 January 2018

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Human osteosarcoma cells spontaneously release matrix-vesicle-like structures with the capacity to mineralize

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M303136200

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4 December 2017

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