Simulations of a G protein-coupled receptor homology model predict dynamic features and a ligand binding site (Q44559624)

4 December 2017

Simulations of a G protein-coupled receptor homology model predict dynamic features and a ligand binding site (English)

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G protein-coupled receptor

4 December 2017

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Steffen Wolf

1

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Klaus Gerwert

series ordinal

5

object named as

Klaus Gerwert

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4 December 2017

4

Jürgen Schlitter

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4 December 2017

Marcus Böckmann

2

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PubMed ID

18775703

4 December 2017

Udo Höweler

series ordinal

3

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PubMed ID

18775703

4 December 2017

language of work or name

English

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publication date

5 September 2008

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4 December 2017

8

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based on heuristic

inferred from page(s)

published in

FEBS Letters

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4 December 2017

582

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4 December 2017

23-24

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4 December 2017

3335-3342

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Seven-transmembrane receptors

4 December 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2008.08.022

Latest development in drug discovery on G protein-coupled receptors

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1 reference

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Crystal structure of rhodopsin: A G protein-coupled receptor

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The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure

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Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

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Molecular dynamics simulations of bovine rhodopsin: influence of protonation states and different membrane-mimicking environments

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Membrane model for the G-protein-coupled receptor rhodopsin: hydrophobic interface and dynamical structure

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1 reference

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Protein-based virtual screening of chemical databases. II. Are homology models of G-Protein Coupled Receptors suitable targets?

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1 reference

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Three-Dimensional Models for β-Adrenergic Receptor Complexes with Agonists and Antagonists

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Predicted 3D structure for the human beta 2 adrenergic receptor and its binding site for agonists and antagonists

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Toward the active conformations of rhodopsin and the beta2-adrenergic receptor

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1 reference

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Dynamic behavior of fully solvated beta2-adrenergic receptor, embedded in the membrane with bound agonist or antagonist.

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1 reference

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Molecular dynamics simulation of the P2Y14 receptor. Ligand docking and identification of a putative binding site of the distal hexose moiety

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Molecular dynamics simulation of the human adenosine A3 receptor: agonist induced conformational changes of Trp243.

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Structure and dynamics of the full-length M1 muscarinic acetylcholine receptor studied by molecular dynamics simulations

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Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states

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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

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Light-driven activation of beta 2-adrenergic receptor signaling by a chimeric rhodopsin containing the beta 2-adrenergic receptor cytoplasmic loops

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GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

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A graph-theory algorithm for rapid protein side-chain prediction

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Bioinformatic tools uncover the C-terminal strand of Rubisco's large subunit as hot-spot for specificity-enhancing mutations.

21 January 2018

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GROMACS: fast, flexible, and free

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Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperature

21 January 2018

1 reference

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Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: a Fourier-transform infrared spectroscopy study of site-directed mutants.

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1 reference

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Dynamics of water molecules in the bacteriorhodopsin trimer in explicit lipid/water environment

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Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor

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Role of group-conserved residues in the helical core of beta2-adrenergic receptor

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Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

21 January 2018

1 reference

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The forgotten serine. A critical role for Ser-2035.42 in ligand binding to and activation of the beta 2-adrenergic receptor.

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Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor

21 January 2018

1 reference

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Mutation of Asn293 to Asp in transmembrane helix VI abolishes agonist-induced but not constitutive activity of the beta(2)-adrenergic receptor

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1 reference

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10.1016/J.FEBSLET.2008.08.022

21 January 2018

Identifiers

DOI

1 reference

4 December 2017

1 reference

PubMed ID

18775703