Phe783, Thr797, and Asp804 in transmembrane hairpin M5-M6 of Na+,K+-ATPase play a key role in ouabain binding. (Q44583892)

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8 November 2019

title

Phe783, Thr797, and Asp804 in transmembrane hairpin M5-M6 of Na+,K+-ATPase play a key role in ouabain binding (English)

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8 November 2019

main subject

transmembrane protein

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author

Peter H Willems

4

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8 November 2019

author name string

Li Yan Qiu

1

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8 November 2019

Jan B Koenderink

2

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8 November 2019

Herman G P Swarts

3

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8 November 2019

Jan Joep H H M De Pont

5

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8 November 2019

language of work or name

English

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publication date

12 September 2003

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Journal of Biological Chemistry

8 November 2019

published in

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8 November 2019

volume

278

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8 November 2019

issue

47

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8 November 2019

page(s)

47240-47244

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Structure-function relationships in the Na,K-ATPase alpha subunit: site-directed mutagenesis of glutamine-111 to arginine and asparagine-122 to aspartic acid generates a ouabain-resistant enzyme

8 November 2019

cites work

1 reference

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Extensive random mutagenesis analysis of the Na+/K+-ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity--implications for ouabain binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308833200

Random mutagenesis of the sheep Na,K-ATPase alpha1 subunit generating the ouabain-resistant mutant L793P.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308833200

High-affinity ouabain binding by a chimeric gastric H+,K+-ATPase containing transmembrane hairpins M3-M4 and M5-M6 of the alpha 1-subunit of rat Na+,K+-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308833200

Na(+)-, ouabain-, Ca(2+)-, and thapsigargin-sensitive ATPase activity expressed in chimeras between the calcium and the sodium pump alpha subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308833200

The amino-terminal 200 amino acids of the plasma membrane Na+,K+-ATPase alpha subunit confer ouabain sensitivity on the sarcoplasmic reticulum Ca(2+)-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308833200

Heteromultimeric CLC chloride channels with novel properties

21 January 2018

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308833200

The beta-subunits of Na+,K+-ATPase and gastric H+,K+-ATPase have a high preference for their own alpha-subunit and affect the K+ affinity of these enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308833200

Membrane disposition of the M5-M6 hairpin of Na+,K(+)-ATPase alpha subunit is ligand dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308833200

Conformational dynamics of the Na+/K+-ATPase probed by voltage clamp fluorometry

21 January 2018

1 reference

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A chimeric gastric H+,K+-ATPase inhibitable with both ouabain and SCH 28080.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308833200

Mutation of aspartate 804 of Na(+),K(+)-ATPase modifies the cation binding pocket and thereby generates a high Na(+)-ATPase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308833200

Structural changes in the calcium pump accompanying the dissociation of calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308833200

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

21 January 2018

1 reference

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Structural insights into the binding of cardiac glycosides to the digitalis receptor revealed by solid-state NMR

21 January 2018

1 reference

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The influence of some cations on an adenosine triphosphatase from peripheral nerves

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308833200

21 January 2018

Identifiers

DOI

10.1074/JBC.M308833200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12972417%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

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