Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: effect of the benzimidazolone derivative NS004. (Q44591746)

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scientific article published in July 2003

Language	Label	Description	Also known as
English	Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: effect of the benzimidazolone derivative NS004.	scientific article published in July 2003

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14502435%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: effect of the benzimidazolone derivative NS004 (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14502435%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

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Frédéric Becq

3

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19 December 2019

author name string

R Dérand

1

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19 December 2019

L Bulteau-Pignoux

2

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19 December 2019

publication date

1 July 2003

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19 December 2019

number of pages

9

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Journal of Membrane Biology

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19 December 2019

194

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19 December 2019

2

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19 December 2019

109-117

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19 December 2019

https://scigraph.springernature.com/pub.10.1007/s00232-003-2030-z

0 references

Structural basis for specificity and potency of xanthine derivatives as activators of the CFTR chloride channel.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective function of the cystic fibrosis-causing missense mutation G551D is recovered by genistein

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology of CFTR chloride channel activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chloride Conductance Expressed by ΔF508 and Other Mutant CFTRs In Xenopus Oocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A1 adenosine-receptor antagonists activate chloride efflux from cystic fibrosis cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of chloride channel modulators

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological basis of cystic fibrosis: a historical perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correction of delF508-CFTR activity with benzo(c)quinolizinium compounds through facilitation of its processing in cystic fibrosis airway cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coupling of CFTR Cl- channel gating to an ATP hydrolysis cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of Cl- secretion by benzimidazolones. II. Coordinate regulation of apical GCl and basolateral GK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of CFTR channel gating

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of G551D CFTR channel with MPB-91: regulation by ATPase activity and phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of substituted Benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleoside triphosphates are required to open the CFTR chloride channel.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties of CFTR activated by the xanthine derivative X-33 in human airway Calu-3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatase inhibitors activate normal and defective CFTR chloride channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genistein modifies the activation kinetics and magnitude of phosphorylated wild-type and G551D-CFTR chloride currents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP-independent activation of CFTR Cl channels by the tyrosine kinase inhibitor genistein

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cystic fibrosis transmembrane conductance regulator activation by cAMP-independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP- and Ca2+-independent activation of cystic fibrosis transmembrane conductance regulator channels by phenylimidazothiazole drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cystic fibrosis mutation G551D alters the non-Michaelis-Menten behavior of the cystic fibrosis transmembrane conductance regulator (CFTR) channel and abolishes the inhibitory Genistein binding site.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation by cAMP-dependent protein kinase causes a conformational change in the R domain of the cystic fibrosis transmembrane conductance regulator

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CFTR-mediated chloride permeability is regulated by type III phosphodiesterases in airway epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cystic fibrosis transmembrane conductance regulator mutations that disrupt nucleotide binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A change in gating mode leading to increased intrinsic Cl- channel activity compensates for defective processing in a cystic fibrosis mutant corresponding to a mild form of the disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological modulation of ion transport across wild-type and DeltaF508 CFTR-expressing human bronchial epithelia

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATPase activity of the cystic fibrosis transmembrane conductance regulator

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional roles of the nucleotide-binding folds in the activation of the cystic fibrosis transmembrane conductance regulator

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The substituted benzimidazolone NS004 is an opener of the cystic fibrosis chloride channel.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATP hydrolysis by a CFTR domain: pharmacology and effects of G551D mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A common mechanism for cystic fibrosis transmembrane conductance regulator protein activation by genistein and benzimidazolone analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple assay for agonist-regulated Cl and K conductances in salt-secreting epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14502435

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00232-003-2030-Z

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14502435%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14502435%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

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