A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis (Q44596853)

4 December 2017

A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis (English)

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Naiara Rodríguez-Ezpeleta

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A Alcina

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Elena Urcelay

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Koen Vandenbroeck

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Stacy J. Caillier

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S Caillier

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J R Oksenberg

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X Montalban

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J Alvarez

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B Swaminathan

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I Alloza

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M Comabella

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M Fedetz

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M A Ortiz

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G Izquierdo

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O Fernandez

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R Arroyo

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A Antigüedad

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A Aransay

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30 June 2011

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inferred from page(s)

published in

Genes and Immunity

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21-28

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https://scigraph.springernature.com/pub.10.1038/gene.2011.44

4 December 2017

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Risk alleles for multiple sclerosis identified by a genomewide study

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Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

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IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci

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Glutamate-mediated glial injury: mechanisms and clinical importance

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The expanding genetic overlap between multiple sclerosis and type I diabetes

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Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T.

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Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis

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Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis.

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Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.

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SOCS1 and SOCS3 in the control of CNS immunity

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Regulation of signal transducer and activator of transcription and suppressor of cytokine-signaling gene expression in the brain of mice with astrocyte-targeted production of interleukin-12 or experimental autoimmune encephalomyelitis

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Treatment of mice with the suppressor of cytokine signaling-1 mimetic peptide, tyrosine kinase inhibitor peptide, prevents development of the acute form of experimental allergic encephalomyelitis and induces stable remission in the chronic relapsing

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Functional SOCS1 polymorphisms are associated with variation in obesity in whites.

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Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

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Coordinate expression of the PRM1, PRM2, and TNP2 multigene locus in human testis.

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A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

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No gene is an island: the flip-flop phenomenon

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Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor

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Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection.

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Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations

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New diagnostic criteria for multiple sclerosis: guidelines for research protocols

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Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies

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SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap

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Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis

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Functional Polymorphism in theSuppressor of Cytokine Signaling 1Gene Associated with Adult Asthma

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IL-22RA2 Associates with Multiple Sclerosis and Macrophage Effector Mechanisms in Experimental Neuroinflammation

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IL7RA polymorphisms and susceptibility to multiple sclerosis

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7 January 2021

Differential expression of SOCS1 in macrophages in relapsing-remitting and chronic EAE and its role in disease severity

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7 January 2021

Differential expression of suppressors of cytokine signaling-1 and -3 and related cytokines in central nervous system during remitting versus non-remitting forms of experimental autoimmune encephalomyelitis.

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7 January 2021

Interferon-gamma-oligodendrocyte interactions in the regulation of experimental autoimmune encephalomyelitis

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7 January 2021

Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads

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7 January 2021

Identifiers

DOI

10.1038/GENE.2011.44

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4 December 2017

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