Improving protein pharmacokinetics by genetic fusion to simple amino acid sequences (Q44652104)

5 December 2017

Improving protein pharmacokinetics by genetic fusion to simple amino acid sequences (English)

1 reference

5 December 2017

1 reference

2

1 reference

5 December 2017

3

1 reference

5 December 2017

Paula Alvarez

1

1 reference

PubMed ID

14612434

5 December 2017

language of work or name

English

0 references

publication date

11 November 2003

1 reference

Journal of Biological Chemistry

5 December 2017

1 reference

5 December 2017

279

1 reference

5 December 2017

3375-3381

1 reference

5 December 2017

5

1 reference

The N-glycans determine the differential blood clearance and hepatic uptake of human immunoglobulin (Ig)A1 and IgA2 isotypes

5 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Mutation of any site of N-linked glycosylation accelerates the in vivo clearance of recombinant rabbit antithrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Modulation of circulatory residence of recombinant acetylcholinesterase through biochemical or genetic manipulation of sialylation levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Effect of human acetylcholinesterase subunit assembly on its circulatory residence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Multiple roles for the major histocompatibility complex class I- related receptor FcRn

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Increased endosomal sorting of ligand to recycling enhances potency of an interleukin-2 analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Identifying amino acid residues that influence plasma clearance of murine IgG1 fragments by site-directed mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Introduction and overview of peptide and protein pegylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Increasing the serum persistence of an IgG fragment by random mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Rational cytokine design for increased lifetime and enhanced potency using pH-activated "histidine switching".

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Immunoadhesins as research tools and therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Convergent evolution among immunoglobulin G-binding bacterial proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Structure of a group C streptococcal protein that binds to fibrinogen, albumin and immunoglobulin G via overlapping modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Albumin binding as a general strategy for improving the pharmacokinetics of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Functional diversity in the trans-sialidase and mucin families in Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

A recombinant Trypanosoma cruzi trans-sialidase lacking the amino acid repeats retains the enzymatic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Thymocyte depletion in Trypanosoma cruzi infection is mediated by trans-sialidase-induced apoptosis on nurse cells complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

A superfamily of Trypanosoma cruzi surface antigens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Identification of a Trypanosoma cruzi antigen that is shed during the acute phase of Chagas' disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Gene discovery in the freshwater fish parasite Trypanosoma carassii: identification of trans-sialidase-like and mucin-like genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

A novel proline-rich protein, EspF, is secreted from enteropathogenic Escherichia coli via the type III export pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

A gene from the locus of enterocyte effacement that is required for enteropathogenic Escherichia coli to increase tight-junction permeability encodes a chaperone for EspF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Multiple overlapping epitopes in the repetitive unit of the shed acute-phase antigen from Trypanosoma cruzi enhance its immunogenic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Long-lasting antibodies detected by a trans-sialidase inhibition assay of sera from parasite-free, serologically cured chagasic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Design of yeast-secreted albumin derivatives for human therapy: biological and antiviral properties of a serum albumin-CD4 genetic conjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Generating improved single-chain Fv molecules for tumor targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

The potential for enhanced tumour localisation by poly(ethylene glycol) modification of anti-CEA antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Long-acting growth hormones produced by conjugation with polyethylene glycol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Pharmacokinetic and pharmacodynamic studies of a human serum albumin-interferon-alpha fusion protein in cynomolgus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

The structure and function of proline-rich regions in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Biased amino acid composition in repeat regions of Plasmodium antigens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Diversity in repeat-containing surface proteins of Leishmania major.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

Therapeutic antibody fragments with prolonged in vivo half-lives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

trans‐Sialidase fromTrypanosoma cruziInduces Apoptosis in Cells from the Immune System In Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311356200

21 January 2018

Identifiers

DOI

10.1074/JBC.M311356200

1 reference

5 December 2017

1 reference

PubMed ID

14612434