Intracellular phosphorylation of zidovudine (ZDV) and other nucleoside reverse transcriptase inhibitors (RTI) used for human immunodeficiency virus (HIV) infection (Q44657491)

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scientific article published in June 1998

Language	Label	Description	Also known as
English	Intracellular phosphorylation of zidovudine (ZDV) and other nucleoside reverse transcriptase inhibitors (RTI) used for human immunodeficiency virus (HIV) infection	scientific article published in June 1998

Statements

scholarly article

1 reference

Europe PubMed Central

5 December 2017

1 reference

Europe PubMed Central

Intracellular phosphorylation of zidovudine (ZDV) and other nucleoside reverse transcriptase inhibitors (RTI) used for human immunodeficiency virus (HIV) infection (English)

1 reference

Europe PubMed Central

5 December 2017

phosphorylation

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based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

K Peter

1

1 reference

Europe PubMed Central

5 December 2017

J G Gambertoglio

2

1 reference

Europe PubMed Central

5 December 2017

publication date

1 June 1998

1 reference

Europe PubMed Central

5 December 2017

Pharmaceutical Research

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Europe PubMed Central

5 December 2017

15

1 reference

Europe PubMed Central

5 December 2017

6

1 reference

Europe PubMed Central

5 December 2017

819-825

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Europe PubMed Central

5 December 2017

The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Initial studies on the cellular pharmacology of 2',3'-dideoxyinosine, an inhibitor of HIV infectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of Lymphocytopathic Retroviruses from San Francisco Patients with AIDS

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacokinetics of nucleoside antiretroviral agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human immunodeficiency virus I-induced expression of P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity of 3'-azido-3'-deoxythymidine correlates with 3'-azidothymidine-5'-monophosphate (AZTMP) levels, whereas anti-human immunodeficiency virus (HIV) activity correlates with 3'-azidothymidine-5'-triphosphate (AZTTP) levels in cultured CEM T

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A sensitive nonisotopic method for the determination of intracellular azidothymidine 5′-mono-, 5′-di-, and 5′-triphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of intracellular zidovudine phosphates by use of combined cartridge-radioimmunoassay methodology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular zidovudine (ZDV) and ZDV phosphates as measured by a validated combined high-pressure liquid chromatography-radioimmunoassay procedure

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein (MDR 1 gene product) in cells of the immune system: its possible physiologic role and alteration in aging and human immunodeficiency virus-1 (HIV-1) infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of in vitro development of drug resistance to azidothymidine in T-lymphocytic leukemia cell lines (Jurkat E6-1/AZT-100) and in pediatric patients with HIV-1 infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zidovudine phosphorylation after short-term and long-term therapy with zidovudine in patients infected with the human immunodeficiency virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance of HIV-1 to AZT might also involve the cellular expression of multidrug resistance P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of HIV infection of resting peripheral blood lymphocytes by nucleosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of zidovudine phosphorylation in peripheral blood mononuclear cells from patients infected with human immunodeficiency virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular metabolism of 3'-azidothymidine in isolated human peripheral blood mononuclear cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zidovudine phosphorylation in HIV-infected patients and seronegative volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiretroviral therapy for human immunodeficiency virus infection in 1997.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantification of zidovudine and individual zidovudine phosphates in peripheral blood mononuclear cells by a combined isocratic high performance liquid chromatography radioimmunoassay method

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular metabolism of zidovudine and stavudine in combination

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Divergent anti-human immunodeficiency virus activity and anabolic phosphorylation of 2',3'-dideoxynucleoside analogs in resting and activated human cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-human immunodeficiency virus type 1 activity of hydroxyurea in combination with 2',3'-dideoxynucleosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of zidovudine (AZT) resistance in Jurkat T cells is associated with decreased expression of the thymidine kinase (TK) gene and hypermethylation of the 5' end of human TK gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3'-azido-3'-deoxythymidine. An unusual nucleoside analogue that permeates the membrane of human erythrocytes and lymphocytes by nonfacilitated diffusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Initial studies on the cellular pharmacology of 2',3-dideoxycytidine, an inhibitor of HTLV-III infectivity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between lamivudine (3TC) and other nucleoside analogues for intracellular phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A method for the quantification of intracellular zidovudine nucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of mammalian DNA polymerase-associated 3' to 5' exonuclease activity by 5'-monophosphates of 3'-azido-3'-deoxythymidine and 3'-amino-3'-deoxythymidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic assay for measurement of zidovudine triphosphate in peripheral blood mononuclear cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic phosphorylation and pyrophosphorylation of 2',3'-dideoxyadenosine-5'-monophosphate, a key metabolite in the pathway for activation of the anti-HIV (human immunodeficiency virus) agent 2',3'-dideoxyinosine

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular metabolism of (−) enantiomeric 2′-deoxy-3′-thiacytidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Viral dynamics in human immunodeficiency virus type 1 infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/9647345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1011956011207

1 reference

Europe PubMed Central

5 December 2017

1 reference

Europe PubMed Central

5 December 2017

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