Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity (Q44689531)

5 December 2017

Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity (English)

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5 December 2017

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5 December 2017

Thomas Decker

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Mathias Müller

object named as

Mathias Müller

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author name string

Louisa Varinou

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5 December 2017

Katrin Ramsauer

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5 December 2017

Marina Karaghiosoff

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5 December 2017

Thomas Kolbe

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5 December 2017

language of work or name

English

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publication date

1 December 2003

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5 December 2017

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5 December 2017

19

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5 December 2017

6

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5 December 2017

793-802

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Stat1-dependent, p53-independent expression of p21(waf1) modulates oxysterol-induced apoptosis

5 December 2017

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Genomic organization and chromosomal localization of a new member of the murine interferon-induced guanylate-binding protein family

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Interferon regulatory factor 1 is required for mouse Gbp gene activation by gamma interferon

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Interferon gamma receptor deficient mice are resistant to endotoxic shock

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Activation of protein kinase C delta by IFN-gamma

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Serine phosphorylation of STATs

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Partial impairment of cytokine responses in Tyk2-deficient mice

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Involvement of the IRF-1 transcription factor in antiviral responses to interferons

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Stats: transcriptional control and biological impact

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Activation of the transcription factor ISGF3 by interferon-gamma

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Interferon alpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Phosphorylation of the Stat1 transactivating domain is required for the response to type I interferons

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727.

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Distinct transcriptional activation functions of STAT1alpha and STAT1beta on DNA and chromatin templates

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https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900322-4

7 January 2021

10.1016/S1074-7613(03)00322-4

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DOI

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5 December 2017

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