Sensitivity and specificity of isolated perfused guinea pig heart to test for drug-induced lengthening of QTc. (Q44689852)

5 December 2017

title

Sensitivity and specificity of isolated perfused guinea pig heart to test for drug-induced lengthening of QTc. (English)

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5 December 2017

Hamlin RL

1

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5 December 2017

Cruze CA

2

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5 December 2017

Mittelstadt SW

3

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5 December 2017

Kijtawornrat A

4

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5 December 2017

Keene BW

5

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5 December 2017

Roche BM

6

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5 December 2017

Nakayama T

7

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5 December 2017

Nakayama H

8

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5 December 2017

Hamlin DM

9

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5 December 2017

Arnold T

10

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5 December 2017

publication date

1 January 2004

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Journal of Pharmacological and Toxicological Methods

5 December 2017

published in

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5 December 2017

volume

49

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5 December 2017

issue

1

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5 December 2017

page(s)

15-23

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Sparfloxacin but not levofloxacin or ofloxacin prolongs cardiac repolarization in rabbit Purkinje fibers

5 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Electrophysiological and arrhythmogenic effects of the histamine type 1-receptor antagonist astemizole on rabbit Purkinje fibers: clinical relevance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Cellular and Ionic Mechanisms Underlying Erythromycin-Induced Long QT Intervals and Torsade de Pointes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Clozapine and new-onset ECG abnormalities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Time-dependent outward current in guinea pig ventricular myocytes. Gating kinetics of the delayed rectifier

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Acute effects of escalating doses of amiodarone in isolated guinea pig hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Probucol. A reappraisal of its pharmacological properties and therapeutic use in hypercholesterolaemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

An isolated guinea pig heart preparation with in vivo like features

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

The novel class III antiarrhythmics NE-10064 and NE-10133 inhibit IsK channels expressed in Xenopus oocytes and IKs in guinea pig cardiac myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Electrophysiological effects of encainide on isolated cardiac muscle and Purkinje fibers and on the Langendorff-perfused guinea-pig heart.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Comparative effects of lignocaine and lorcainide on conduction in the Langendorff-perfused guinea-pig heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Drugs that prolong QT interval as an unwanted effect: assessing their likelihood of inducing hazardous cardiac dysrhythmias

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Mexiletine antagonizes effects of sotalol on QT interval duration and its proarrhythmic effects in a canine model of torsade de pointes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Erythromycin blocks the rapid component of the delayed rectifier potassium current and lengthens repolarization of guinea pig ventricular myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Effects of a single oral dose of sparfloxacin on ventricular repolarization in healthy volunteers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Torsade de pointes caused by high‐dose intravenous haloperidol in cardiac patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Computerized evaluation of drug-induced changes in guinea-pig epicardial monophasic action potentials.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Experimental models of torsade de pointes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Sodium-calcium exchange during the action potential in guinea-pig ventricular cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Effect of verapamil on QT interval dynamicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Generating and influencing Torsades de Pointes--like polymorphic ventricular tachycardia in isolated guinea pig hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Use-dependent block of the pacemaker current I(f) in rabbit sinoatrial node cells by zatebradine (UL-FS 49). On the mode of action of sinus node inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Hemodynamic and electrophysiologic effects of ontazolast in dogs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Relationship between QaT and RR intervals in rats, guinea pigs, rabbits, and primates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Adrenoceptor-mediated changes of excitation and contraction in ventricular heart muscle from guinea-pigs and rabbits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Proarrhythmia with class III antiarrhythmic drugs: types, risks, and management

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Clofilium in the isolated perfused rabbit heart: a new model to study proarrhythmia induced by class III antiarrhythmic drugs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Antiarrhythmic drug carvedilol inhibits HERG potassium channels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Depressant effect of magnesium on early afterdepolarizations and triggered activity induced by cesium, quinidine, and 4-aminopyridine in canine cardiac Purkinje fibers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Effects of Amiodarone and Bepridil on Ventricular Depolarization and Repolarizationa

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Terfenadine alters action potentials in isolated canine Purkinje fibers more than acrivastine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Electrophysiological profile of the antiarrhythmic compound asocainol studied on perfused guinea-pig hearts and on isolated cardiac preparations.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Electrophysiologic and hemodynamic effects of apomorphine in dogs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Erythromycin-induced long QT syndrome: concordance with quinidine and underlying cellular electrophysiologic mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Screening lead compounds for QT interval prolongation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Bepridil prolongs the action potential duration of guinea pig ventricular muscle only at rapid rates of stimulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Terfenadine increases the QT interval in isolated guinea pig heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Cisapride-induced prolongation of cardiac action potential and early afterdepolarizations in rabbit Purkinje fibres.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Quinidine delays IK activation in guinea pig ventricular myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Cellular electrophysiology of digitalis toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Electrophysiological mechanisms in a canine model of erythromycin-associated long QT syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Sodium pentobarbital reduces transmural dispersion of repolarization and prevents torsades de Pointes in models of acquired and congenital long QT syndrome.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Continuous ECG measurements of intracardiac activity from the surface of Langendorff-perfused guinea pig hearts.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Modulation of cardiac impulse generation and conduction by nifedipine and verapamil analyzed by a refined surface ECG technique in Langendorff perfused guinea pig hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Assessment of the conduction of the cardiac impulse by a new epicardiac surface and stimulation technique (SST-ECG) in Langendorff perfused mammalian hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Effects of nonsedating antihistamine, astemizole, on the in situ canine heart assessed by cardiohemodynamic and monophasic action potential monitoring

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

7 January 2021

Delusion of pregnancy

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Triggered activity and automaticity in ventricular trabeculae of failing human and rabbit hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Reproducible induction of early afterdepolarizations and torsade de pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Tissue and species distribution of mRNA for the IKr-like K+ channel, erg.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Electrophysiologic features of torsades de pointes: insights from a new isolated rabbit heart model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

Mechanism of block and identification of the verapamil binding domain to HERG potassium channels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

The use of Xenopus oocytes for the study of ion channels.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2003.08.003

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.VASCN.2003.08.003

1 reference

5 December 2017

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