Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels (Q44697518)

5 December 2017

title

Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels (English)

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5 December 2017

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Naoki Morito

1

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5 December 2017

Keigyou Yoh

2

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5 December 2017

Ken Itoh

3

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5 December 2017

Aki Hirayama

4

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5 December 2017

Akio Koyama

5

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5 December 2017

Masayuki Yamamoto

6

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5 December 2017

Satoru Takahashi

7

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5 December 2017

language of work or name

English

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publication date

1 December 2003

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5 December 2017

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5 December 2017

volume

22

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5 December 2017

issue

58

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5 December 2017

page(s)

9275-9281

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207024

5 December 2017

exact match

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cites work

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An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

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Role of NRF2 in protection against hyperoxic lung injury in mice

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High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

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Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage.

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Review: The role of glutathione in the regulation of apoptosis

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Prolonged, but not acute, glutathione depletion promotes Fas-mediated mitochondrial permeability transition and apoptosis in mice

21 January 2018

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Depletion of hepatic glutathione prevents death receptor-dependent apoptotic and necrotic liver injury in mice

21 January 2018

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CD95-Mediated murine hepatic apoptosis requires an intact glutathione status

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Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis

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Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

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An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

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Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins

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Regulatory mechanisms of cellular response to oxidative stress

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Nrf2 is an inhibitor of the Fas pathway as identified by Achilles' Heel Method, a new function-based approach to gene identification in human cells

21 January 2018

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FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

21 January 2018

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On the antioxidant effects of ascorbic acid and glutathione

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Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

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Apoptosis by death factor

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Lethal effect of the anti-Fas antibody in mice

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Oxidant-mediated lung epithelial cell tolerance: the role of intracellular glutathione and nuclear factor-kappaB.

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

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Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds

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Potentiation of benzo[a]pyrene-induced pulmonary and forestomach tumorigenesis in mice by D,L-buthionine-S,R-sulfoximine-mediated tissue glutathione depletion.

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Apoptosis signaling by death receptors.

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21 January 2018

Caspases: enemies within

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The physiological consequences of glutathione variations.

21 January 2018

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Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

21 January 2018

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Glutathione modulates rat and mouse hepatocyte sensitivity to tumor necrosis factor toxicity

21 January 2018

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Nrf2-deficient female mice develop lupus-like autoimmune nephritis

21 January 2018

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Involvement of cellular proteolytic machinery in apoptosis

21 January 2018

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Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor

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Glutathione monoethyl ester protects against glutathione deficiencies due to aging and acetaminophen in mice

21 January 2018

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7 January 2021

Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells

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7 January 2021

Functions of glutathione and glutathione disulfide in immunology and immunopathology.

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7 January 2021

Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE)

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207024

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5 December 2017

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