Overexpression of CYP2D6 attenuates the toxicity of MPP+ in actively dividing and differentiated PC12 cells (Q44700084)

21 June 2018

title

Overexpression of CYP2D6 attenuates the toxicity of MPP+ in actively dividing and differentiated PC12 cells (English)

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21 June 2018

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6

Eliezer Masliah

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21 June 2018

Naomi Matoh

1

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21 June 2018

Seigo Tanaka

2

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21 June 2018

Masanori Takehashi

3

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21 June 2018

Marek Banasik

4

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21 June 2018

Todd Stedeford

5

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21 June 2018

Shigehiko Suzuki

7

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21 June 2018

Yoshihiko Nishimura

8

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21 June 2018

Kunihiro Ueda

9

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21 June 2018

publication date

1 January 2003

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21 June 2018

published in

Gene Expression

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21 June 2018

volume

11

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21 June 2018

issue

3-4

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21 June 2018

page(s)

117-124

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21 June 2018

Organochlorine insecticides in substantia nigra in Parkinson's disease

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Pramipexole reduces reactive oxygen species production in vivo and in vitro and inhibits the mitochondrial permeability transition produced by the parkinsonian neurotoxin methylpyridinium ion.

22 June 2018

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Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes

22 June 2018

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Isoquinoline neurotoxins in the brain and Parkinson's disease

22 June 2018

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Mitochondrial toxins in models of neurodegenerative diseases. I: In vivo brain hydroxyl radical production during systemic MPTP treatment or following microdialysis infusion of methylpyridinium or azide ions

22 June 2018

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Genetic elevation of monoamine oxidase levels in dopaminergic PC12 cells results in increased free radical damage and sensitivity to MPTP.

22 June 2018

1 reference

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Oxygen activation by cytochrome P-450.

22 June 2018

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

22 June 2018

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Metabolism of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by liver homogenate fractions

22 June 2018

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Characterization of hepatic microsomal metabolism as an in vivo detoxication pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice

22 June 2018

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Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine

22 June 2018

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The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene

22 June 2018

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Effects of N-methylmercaptoimidazole on the disposition of MPTP and its metabolites in mice.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991163

Studies on the cytochrome P-450 catalyzed ring alpha-carbon oxidation of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

22 June 2018

1 reference

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Identification of the primary gene defect at the cytochrome P450 CYP2D locus.

22 June 2018

1 reference

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Acute Effects of 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine in a Model of Rat Designated a Poor Metabolizer of Debrisoquine

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991163

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991163

Association of CYP2D microsatellite polymorphism with Lewy body variant of Alzheimer's disease

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991163

Gene-toxin interaction as a putative risk factor for Parkinson's disease with dementia

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991163

Diorthosubstituted polychlorinated biphenyls in caudate nucleus in Parkinson's disease.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991163

Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991163

Redox cycling of MPP+: evidence for a new mechanism involving hydride transfer with xanthine oxidase, aldehyde dehydrogenase, and lipoamide dehydrogenase.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991163

Parkinson's disease and brain levels of organochlorine pesticides.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991163

Effect of auto-oxidized phospholipids on oxidative enzyme assays based on tetrazolium salt reduction.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991163

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5991163

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.

15 August 2018

1 reference

12 December 2020

Contribution of N-oxygenation to the metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) by various liver preparations

1 reference

12 December 2020

Studies on the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine cytotoxicity in isolated hepatocytes

1 reference

12 December 2020

Metabolism and brain accumulation of tetrahydroisoquinoline (TIQ) a possible parkinsonism inducing substance, in an animal model of a poor debrisoquine metabolizer

1 reference

12 December 2020

Measurement of human liver microsomal cytochrome P450 2D6 activity using [O-methyl-14C]dextromethorphan as substrate

1 reference

12 December 2020

MPTP fails to induce lipid peroxidation in vivo

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12 December 2020

Dihydrotetramethylrosamine: a long wavelength, fluorogenic peroxidase substrate evaluated in vitro and in a model phagocyte

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12 December 2020

10.3727/000000003108749017

Identifiers

DOI

1 reference

21 June 2018

PMCID

5991163

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21 June 2018

PubMed ID

14686785

1 reference

21 June 2018