Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice (Q44719693)

5 December 2017

Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice (English)

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5 December 2017

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Martha Campbell-Thompson

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Song S

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Goudy K

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Scott-Jorgensen M

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Wang J

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Tang Q

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Crawford JM

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Ellis TM

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Atkinson MA

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Flotte TR

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1 January 2004

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181-186

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3302156

5 December 2017

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cites work

The NOD mouse model of type 1 diabetes: as good as it gets?

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Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

21 January 2018

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Prevention of diabetes in BioBreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells

21 January 2018

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T-lymphocyte clone specific for pancreatic islet antigen

21 January 2018

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SERP1, a serine proteinase inhibitor encoded by myxoma virus, is a secreted glycoprotein that interferes with inflammation

21 January 2018

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Novel functions of human alpha(1)-protease inhibitor after S-nitrosylation: inhibition of cysteine protease and antibacterial activity.

21 January 2018

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Alpha-1-antitrypsin immunoreactivity in islet cells of adult human pancreas

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302156

Expression of the alpha 1-proteinase inhibitor gene in human monocytes and macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302156

Alpha-1-antitrypsin content in the serum, alveolar macrophages, and alveolar lavage fluid of smoking and nonsmoking normal subjects

21 January 2018

1 reference

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Local control of alpha1-proteinase inhibitor levels: regulation of alpha1-proteinase inhibitor in the human cornea by growth factors and cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302156

Interferon beta 2/interleukin 6 modulates synthesis of alpha 1-antitrypsin in human mononuclear phagocytes and in human hepatoma cells

21 January 2018

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Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects

21 January 2018

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Therapeutic elastase inhibition by alpha-1-antitrypsin gene transfer limits neointima formation in normal rabbits

21 January 2018

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Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors

21 January 2018

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Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors

21 January 2018

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Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice

21 January 2018

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Structure and variation of human alpha 1-antitrypsin

21 January 2018

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Identification of a serpin-enzyme complex receptor on human hepatoma cells and human monocytes

21 January 2018

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Targeted overexpression of elafin protects mice against cardiac dysfunction and mortality following viral myocarditis

21 January 2018

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Chain length of the polylysine in receptor-targeted gene transfer complexes affects duration of reporter gene expression both in vitro and in vivo

21 January 2018

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Adeno-associated virus transduction of islets with interleukin-4 results in impaired metabolic function in syngeneic marginal islet mass transplantation.

21 January 2018

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Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle

21 January 2018

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The murine alpha(1)-proteinase inhibitor gene family: polymorphism, chromosomal location, and structure

21 January 2018

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Autoimmune diabetes in NOD mouse is L3T4 T-lymphocyte dependent

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302156

7 January 2021

Morphological identification of alpha-I-antitrypsin in the human small intestine

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302156

7 January 2021

Human colon carcinoma cells synthesize and secrete alpha 1-proteinase inhibitor

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302156

7 January 2021

Alpha 1-antitrypsin and protease complexation is induced by lipopolysaccharide, interleukin-1beta, and tumor necrosis factor-alpha in monocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302156

7 January 2021

Induction of alpha1-antitrypsin synthesis in human articular chondrocytes by interleukin-6-type cytokines: evidence for a local acute-phase response in the joint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302156

7 January 2021

Acute cigarette smoke-induced connective tissue breakdown is mediated by neutrophils and prevented by alpha1-antitrypsin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302156

7 January 2021

Binding of SPAAT, the 44-residue C-terminal peptide of alpha 1-antitrypsin, to proteins of the extracellular matrix

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302156

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302156

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5 December 2017

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