Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates (Q44719909)

5 December 2017

Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates (English)

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5 December 2017

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Shahrzad Dilmaghanian

1

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5 December 2017

John G Gerber

2

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5 December 2017

Scott G Filler

3

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5 December 2017

Angela Sanchez

4

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5 December 2017

Joseph Gal

5

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5 December 2017

1 February 2004

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5 December 2017

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5 December 2017

16

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5 December 2017

2

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5 December 2017

79-85

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Optically active antifungal azoles. V. Synthesis and antifungal activity of stereoisomers of 3-azolyl-2-(substituted phenyl)-1-(1H-1,2,4-triazol-1-yl)-2- butanols

5 December 2017

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https://api.crossref.org/works/10.1002%2FCHIR.10294

Oral azole drugs as systemic antifungal therapy

21 January 2018

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Comparison of in vitro antifungal activities of topical antimycotics launched in 1990s in Japan

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Stereoisomers of ketoconazole: preparation and biological activity

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine.

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Substrates of human hepatic cytochrome P450 3A4.

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Inhibition and induction of cytochrome P450 and the clinical implications

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients.

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Differential inhibition of human CYP3A4 and Candida albicans CYP51 with azole antifungal agents

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Effects of propofol on human hepatic microsomal cytochrome P450 activities.

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Midazolam alpha-hydroxylation by human liver microsomes in vitro: inhibition by calcium channel blockers, itraconazole and ketoconazole.

1 reference

https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole.

1 reference

https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Intravenous methadone for cancer pain unrelieved by morphine and hydromorphone: clinical observations

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Human cytochromes mediating N-demethylation of fluoxetine in vitro

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Metabolism of gestodene in human liver cytosol and microsomes in vitro

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Fluvoxamine is a more potent inhibitor of lidocaine metabolism than ketoconazole and erythromycin in vitro

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Cytochrome P450 specificity of metabolism and interactions of oxybutynin in human liver microsomes

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

CYP3A4-mediated hepatic metabolism of the HIV-1 protease inhibitor saquinavir in vitro

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Potent mechanism-based inhibition of human CYP3A in vitro by amprenavir and ritonavir: comparison with ketoconazole

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites

1 reference

https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Covalent alteration of the CYP3A4 active site: evidence for multiple substrate binding domains

1 reference

https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Cytochrome P450 conformation and substrate interactions as probed by CO binding kinetics

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Differential inhibition of Candida albicans CYP51 with azole antifungal stereoisomers

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https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences

1 reference

https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate

1 reference

https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Resistance and adaptation to quinidine in Saccharomyces cerevisiae: role of QDR1 (YIL120w), encoding a plasma membrane transporter of the major facilitator superfamily required for multidrug resistance.

1 reference

https://api.crossref.org/works/10.1002%2FCHIR.10294

7 January 2021

Identifiers

DOI

10.1002/CHIR.10294

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5 December 2017

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