The human T-cell leukemia virus type-1 Tax protein regulates the activity of the IkappaB kinase complex (Q44735597)

5 December 2017

The human T-cell leukemia virus type-1 Tax protein regulates the activity of the IkappaB kinase complex (English)

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5 December 2017

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X H Li

1

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5 December 2017

K M Murphy

2

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5 December 2017

K T Palka

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5 December 2017

R M Surabhi

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5 December 2017

R B Gaynor

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5 December 2017

language of work or name

English

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publication date

1 November 1999

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Journal of Biological Chemistry

5 December 2017

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5 December 2017

274

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5 December 2017

48

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5 December 2017

34417-34424

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Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

5 December 2017

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Mechanism of DNA-binding enhancement by the human T-cell leukaemia virus transactivator Tax.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Recognition of bZIP proteins by the human T-cell leukaemia virus transactivator Tax.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Complex formation between CREB and Tax enhances the binding affinity of CREB for the human T-cell leukemia virus type 1 21-base-pair repeats

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Molecular mechanism of tumorigenesis in mice transgenic for the human T cell leukemia virus Tax gene

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

The NF-kappa B and I kappa B proteins: new discoveries and insights

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

NF-kappa B: ten years after

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Inactivation of IkappaBbeta by the tax protein of human T-cell leukemia virus type 1: a potential mechanism for constitutive induction of NF-kappaB

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Identification and characterization of an IkappaB kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Direct Phosphorylation of IB by IKK and IKK: Discrimination Between Free and NF-B-Bound Substrate

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

IKAP is a scaffold protein of the IkappaB kinase complex

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Kinetic analysis of human T-cell leukemia virus type I Tax-mediated activation of NF-kappa B

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Role of unphosphorylated, newly synthesized I kappa B beta in persistent activation of NF-kappa B

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Cdk-activating kinase complex is a component of human transcription factor TFIIH

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

MEK kinase 3 directly activates MKK6 and MKK7, specific activators of the p38 and c-Jun NH2-terminal kinases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

The regulation of anoikis: MEKK-1 activation requires cleavage by caspases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

IKK1-deficient mice exhibit abnormal development of skin and skeleton

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Limb and skin abnormalities in mice lacking IKKalpha

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

Role of Adapter Function in Oncoprotein-mediated Activation of NF-κB

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.34417

21 January 2018

Identifiers

DOI

10.1074/JBC.274.48.34417

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5 December 2017

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