A phase I trial of daily oral 4'- N -benzoyl-staurosporine in combination with protracted continuous infusion 5-fluorouracil in patients with advanced solid malignancies. (Q44739420)

From Wikidata

Jump to navigation Jump to search

scientific article

Language	Label	Description	Also known as
English	A phase I trial of daily oral 4'- N -benzoyl-staurosporine in combination with protracted continuous infusion 5-fluorouracil in patients with advanced solid malignancies.	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

A phase I trial of daily oral 4'- N -benzoyl-staurosporine in combination with protracted continuous infusion 5-fluorouracil in patients with advanced solid malignancies (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

phase I clinical trial

0 references

1 reference

based on heuristic

inferred from title

Rocío García-Carbonero

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

author name string

Joseph P Eder

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Jeffrey W Clark

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Jeffrey G Supko

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Thomas A Puchalski

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

David P Ryan

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Pamela Deluca

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Antoinette Wozniak

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Angela Campbell

9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

John Rothermel

10

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Patricia LoRusso

11

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

publication date

1 April 2004

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Investigational New Drugs

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

22

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

139-150

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

https://scigraph.springernature.com/pub.10.1023/b:drug.0000011790.31292.ef

0 references

Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gas chromatographic-mass spectrometric method for routine monitoring of 5-fluorouracil in plasma of patients receiving low-level protracted infusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase II study of continuous infusion 5-fluorouracil and leucovorin with weekly cisplatin in metastatic colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass spectrometric method in patients on a dose escalation schedule

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Okadaic acid exerts a full insulin-like effect on glucose transport and glucose transporter 4 translocation in human adipocytes. Evidence for a phosphatidylinositol 3-kinase-independent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common noncompartmental pharmacokinetic variables: are they normally or log-normally distributed?

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some practical improvements in the continual reassessment method for phase I studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preparation of mean drug concentration--time curves in plasma. A study on the frequency distribution of pharmacokinetic parameters

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibitory effect of staurosporine on insulin action is prevented by okadaic acid. Evidence for an important role of serine/threonine phosphorylation in eliciting insulin-like effects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C--a novel target for rational anti-cancer drug design?

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Staurosporine analogues - pharmacological toys or useful antitumour agents?

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Practical modifications of the continual reassessment method for phase I cancer clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analytical procedure for the determination of the new antitumour drug N-benzoylstaurosporine and three potential metabolites in human plasma by reversed-phase high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous determination of dihydrofluorouracil and 5-fluorouracil in plasma by high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C isozymes and substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infus

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of protein kinase C in cell surface signal transduction and tumour promotion

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continual reassessment method: a practical design for phase 1 clinical trials in cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C targeting in antineoplastic treatment strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of variance for harmonic mean half-lives.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q44739420&oldid=1749500173"