A phase I trial of daily oral 4'- N -benzoyl-staurosporine in combination with protracted continuous infusion 5-fluorouracil in patients with advanced solid malignancies. (Q44739420)

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English	A phase I trial of daily oral 4'- N -benzoyl-staurosporine in combination with protracted continuous infusion 5-fluorouracil in patients with advanced solid malignancies.	scientific article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

A phase I trial of daily oral 4'- N -benzoyl-staurosporine in combination with protracted continuous infusion 5-fluorouracil in patients with advanced solid malignancies (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739662%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

phase I clinical trial

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Rocío García-Carbonero

2

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17 November 2019

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Joseph P Eder

1

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17 November 2019

Jeffrey W Clark

3

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17 November 2019

Jeffrey G Supko

4

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17 November 2019

Thomas A Puchalski

5

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17 November 2019

David P Ryan

6

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17 November 2019

Pamela Deluca

7

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17 November 2019

Antoinette Wozniak

8

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17 November 2019

Angela Campbell

9

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17 November 2019

John Rothermel

10

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17 November 2019

Patricia LoRusso

11

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17 November 2019

publication date

1 April 2004

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17 November 2019

Investigational New Drugs

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17 November 2019

22

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17 November 2019

2

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17 November 2019

139-150

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17 November 2019

Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

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Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

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Gas chromatographic-mass spectrometric method for routine monitoring of 5-fluorouracil in plasma of patients receiving low-level protracted infusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

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A phase II study of continuous infusion 5-fluorouracil and leucovorin with weekly cisplatin in metastatic colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

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Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass spectrometric method in patients on a dose escalation schedule

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

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Okadaic acid exerts a full insulin-like effect on glucose transport and glucose transporter 4 translocation in human adipocytes. Evidence for a phosphatidylinositol 3-kinase-independent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

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A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

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Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia

1 reference

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12 December 2020

based on heuristic

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Common noncompartmental pharmacokinetic variables: are they normally or log-normally distributed?

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

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Some practical improvements in the continual reassessment method for phase I studies

1 reference

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12 December 2020

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Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling

1 reference

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12 December 2020

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Preparation of mean drug concentration--time curves in plasma. A study on the frequency distribution of pharmacokinetic parameters

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

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The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

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The inhibitory effect of staurosporine on insulin action is prevented by okadaic acid. Evidence for an important role of serine/threonine phosphorylation in eliciting insulin-like effects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

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Protein kinase C--a novel target for rational anti-cancer drug design?

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

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Staurosporine analogues - pharmacological toys or useful antitumour agents?

1 reference

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12 December 2020

based on heuristic

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Practical modifications of the continual reassessment method for phase I cancer clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

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Analytical procedure for the determination of the new antitumour drug N-benzoylstaurosporine and three potential metabolites in human plasma by reversed-phase high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

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Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

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Simultaneous determination of dihydrofluorouracil and 5-fluorouracil in plasma by high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

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Protein kinase C isozymes and substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

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Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infus

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

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The role of protein kinase C in cell surface signal transduction and tumour promotion

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

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Continual reassessment method: a practical design for phase 1 clinical trials in cancer

1 reference

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12 December 2020

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Protein kinase C targeting in antineoplastic treatment strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

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Estimation of variance for harmonic mean half-lives.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14739662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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