Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance (Q44760628)

6 December 2017

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance (English)

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6 December 2017

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Deborah M Muoio

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Gerald I. Shulman

object named as

Gerald I Shulman

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Gary W Cline

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object named as

Gary W Cline

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6 December 2017

Christopher B Newgard

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object named as

Christopher B Newgard

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6 December 2017

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Masakazu Shiota

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Timothy R Koves

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6 December 2017

Jie An

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6 December 2017

Yuka Fujimoto

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6 December 2017

Robert Stevens

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6 December 2017

David Millington

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6 December 2017

language of work or name

English

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publication date

8 February 2004

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6 December 2017

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6 December 2017

10

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6 December 2017

268-274

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https://scigraph.springernature.com/pub.10.1038/nm995

6 December 2017

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cites work

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21 January 2018

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Cellular mechanisms of insulin resistance

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Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats

21 January 2018

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The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes

21 January 2018

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New insights into the mitochondrial carnitine palmitoyltransferase enzyme system

21 January 2018

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Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells

21 January 2018

1 reference

Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice

21 January 2018

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Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.

21 January 2018

1 reference

Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats

21 January 2018

1 reference

Tandem mass spectrometry: a new method for acylcarnitine profiling with potential for neonatal screening for inborn errors of metabolism

21 January 2018

1 reference

Glucose disposal by skeletal muscle in response to re-feeding after progressive starvation

21 January 2018

1 reference

Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes

21 January 2018

1 reference

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

21 January 2018

1 reference

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

21 January 2018

1 reference

A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders

21 January 2018

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PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance

21 January 2018

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PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice

21 January 2018

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Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta

21 January 2018

1 reference

Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles

21 January 2018

1 reference

Insulin resistance in the regulation of lipolysis and ketone body metabolism in non-insulin dependent diabetes is apparent at very low insulin concentrations.

21 January 2018

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Changes in citric acid cycle flux and anaplerosis antedate the functional decline in isolated rat hearts utilizing acetoacetate

21 January 2018

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Coenzyme A sequestration in rat hearts oxidizing ketone bodies

21 January 2018

1 reference

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

21 January 2018

1 reference

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

21 January 2018

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Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets

21 January 2018

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Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

21 January 2018

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The subcellular localization of acetyl-CoA carboxylase 2

21 January 2018

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Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

21 January 2018

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Insulin control of rat hepatocyte glycogen synthase and phosphorylase in the absence of glucose

21 January 2018

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Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis.

21 January 2018

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Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM.

21 January 2018

1 reference

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

21 January 2018

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Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice.

21 January 2018

1 reference

Differentiation-dependent suppression of platelet-derived growth factor signaling in cultured adipocytes

21 January 2018

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Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids

21 January 2018

1 reference

Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia.

21 January 2018

1 reference

7 January 2021

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

1 reference

7 January 2021

Chronic exposure to beta-hydroxybutyrate impairs insulin action in primary cultures of adult cardiomyocytes

1 reference

7 January 2021

Molecular cloning and tissue expression of human mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase

1 reference

7 January 2021

Use of recombinant adenovirus for metabolic engineering of mammalian cells.

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM995

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Dimensions Publication ID

6 December 2017

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