Bcl-xES, a BH4- and BH2-containing antiapoptotic protein, delays Bax oligomer formation and binds Apaf-1, blocking procaspase-9 activation (Q44817169)

6 December 2017

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Bcl-xES, a BH4- and BH2-containing antiapoptotic protein, delays Bax oligomer formation and binds Apaf-1, blocking procaspase-9 activation (English)

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6 December 2017

Estelle Schmitt

1

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6 December 2017

Claudie Paquet

series ordinal

2

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6 December 2017

Myriam Beauchemin

series ordinal

3

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6 December 2017

Richard Bertrand

series ordinal

4

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6 December 2017

language of work or name

English

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publication date

1 May 2004

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6 December 2017

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6 December 2017

23

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6 December 2017

22

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6 December 2017

3915-3931

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207554

6 December 2017

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The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis

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Ikappa b-alpha, the NF-kappa B inhibitory subunit, interacts with ANT, the mitochondrial ATP/ADP translocator

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BCL-2 family: regulators of cell death

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The death inhibitory molecules CED-9 and CED-4L use a common mechanism to inhibit the CED-3 death protease

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Linkage of the BH4 domain of Bcl-2 and the nuclear factor kappaB signaling pathway for suppression of apoptosis

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Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

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Bcl-G, a novel pro-apoptotic member of the Bcl-2 family

21 January 2018

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Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax.

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Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).

21 January 2018

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A splicing variant of the Bcl-2 member Bok with a truncated BH3 domain induces apoptosis but does not dimerize with antiapoptotic Bcl-2 proteins in vitro

21 January 2018

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Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

21 January 2018

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Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death

21 January 2018

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

21 January 2018

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Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane

21 January 2018

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Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

21 January 2018

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Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

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Bcl-xL does not inhibit the function of Apaf-1.

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Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

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A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast

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Channel formation by antiapoptotic protein Bcl-2.

21 January 2018

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Identification and characterization of baxepsilon, a novel bax variant missing the BH2 and the transmembrane domains

21 January 2018

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BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

21 January 2018

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Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity

21 January 2018

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Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

21 January 2018

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Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma

21 January 2018

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Movement of Bax from the cytosol to mitochondria during apoptosis

21 January 2018

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Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

21 January 2018

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A novel splice variant of the cell death-promoting protein BAX.

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Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction

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Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX delta.

21 January 2018

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7 January 2021

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

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7 January 2021

Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex

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7 January 2021

Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death

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7 January 2021

Failure of Bcl-2 family members to interact with Apaf-1 in normal and apoptotic cells

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7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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7 January 2021

A Bad kinase makes good

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7 January 2021

Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis

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7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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7 January 2021

Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.

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7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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7 January 2021

Endonuclease G is an apoptotic DNase when released from mitochondria

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7 January 2021

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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7 January 2021

Bcl-x(L) forms an ion channel in synthetic lipid membranes.

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7 January 2021

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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7 January 2021

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

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7 January 2021

Mitochondrial endonuclease G is important for apoptosis in C. elegans.

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7 January 2021

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

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7 January 2021

Double identity for proteins of the Bcl-2 family

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7 January 2021

Bcl-xL modulates apoptosis induced by anticancer drugs and delays DEVDase and DNA fragmentation-promoting activities

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7 January 2021

Characterization of Bax-sigma, a cell death-inducing isoform of Bax

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7 January 2021

Bax-alpha promotes apoptosis induced by cancer chemotherapy and accelerates the activation of caspase 3-like cysteine proteases in p53 double mutant B lymphoma Namalwa cells

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7 January 2021

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2.

1 reference

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7 January 2021

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1 reference

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7 January 2021

Interaction between the C. elegans cell-death regulators CED-9 and CED-4.

1 reference

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7 January 2021

Mitochondrial release of caspase-2 and -9 during the apoptotic process

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7 January 2021

Molecular characterization of mitochondrial apoptosis-inducing factor

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7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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7 January 2021

Bcl-2 targets the protein kinase Raf-1 to mitochondria

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207554

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207554

7 January 2021

Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207554

7 January 2021

Interaction and regulation of subcellular localization of CED-4 by CED-9

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207554

7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207554

7 January 2021

A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207554

7 January 2021

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207554

7 January 2021

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207554

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207554

1 reference

6 December 2017

1 reference