Transgene expression levels and kinetics determine risk of humoral immune response modeled in factor IX knockout and missense mutant mice. (Q44819846)

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21 December 2019

title

Transgene expression levels and kinetics determine risk of humoral immune response modeled in factor IX knockout and missense mutant mice (English)

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21 December 2019

5

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21 December 2019

author name string

Zhang TP

1

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21 December 2019

Jin DY

2

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21 December 2019

Wardrop RM 3rd

3

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21 December 2019

Gui T

4

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21 December 2019

Frelinger JA

6

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21 December 2019

Stafford DW

7

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21 December 2019

Monahan PE

8

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21 December 2019

language of work or name

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26 October 2006

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21 December 2019

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21 December 2019

volume

14

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21 December 2019

issue

5

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21 December 2019

page(s)

429-440

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3302881

21 December 2019

exact match

0 references

cites work

Haemophilia B: database of point mutations and short additions and deletions--eighth edition

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Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus

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Direct intramuscular injection with recombinant AAV vectors results in sustained expression in a dog model of hemophilia

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Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors

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Persistent expression of canine factor IX in hemophilia B canines

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Sustained expression of therapeutic level of factor IX in hemophilia B dogs by AAV-mediated gene therapy in liver

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Factors influencing in vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA.

21 January 2018

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Sustained phenotypic correction of hemophilia B dogs with a factor IX null mutation by liver-directed gene therapy

21 January 2018

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Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1.

21 January 2018

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Systemic protein delivery by muscle-gene transfer is limited by a local immune response

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Factors influencing cross-presentation of non-self antigens expressed from recombinant adeno-associated virus vectors

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Determination of specific CD4 and CD8 T cell epitopes after AAV2- and AAV8-hF.IX gene therapy

21 January 2018

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Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

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Sustained and complete phenotype correction of hemophilia B mice following intramuscular injection of AAV1 serotype vectors

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Risk and prevention of anti-factor IX formation in AAV-mediated gene transfer in the context of a large deletion of F9.

21 January 2018

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Production of recombinant adeno-associated virus vectors using a packaging cell line and a hybrid recombinant adenovirus

21 January 2018

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Creation of a mouse expressing defective human factor IX

21 January 2018

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Role of vector in activation of T cell subsets in immune responses against the secreted transgene product factor IX.

21 January 2018

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Immune deviation by mucosal antigen administration suppresses gene-transfer-induced inhibitor formation to factor IX.

21 January 2018

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IgG subclass identification of inhibitors to factor IX in haemophilia B patients

21 January 2018

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Measurement of anti-factor IX IgG subclasses in haemophilia B patients who developed inhibitors with episodes of allergic reactions to factor IX concentrates

21 January 2018

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Influence of vector dose on factor IX-specific T and B cell responses in muscle-directed gene therapy

21 January 2018

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Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors

21 January 2018

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Therapeutic levels of factor IX expression using a muscle-specific promoter and adeno-associated virus serotype 1 vector

21 January 2018

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Erythropoietin gene therapy leads to autoimmune anemia in macaques

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Major role of local immune responses in antibody formation to factor IX in AAV gene transfer

21 January 2018

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Immune implications of gene therapy for hemophilia

21 January 2018

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Preclinical and clinical gene therapy for haemophilia

21 January 2018

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AAV-mediated gene transfer for treatment of hemophilia

21 January 2018

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Novel hemophilia B mouse models exhibiting a range of mutations in the Factor IX gene.

21 January 2018

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Identification of T-cell epitopes in clotting factor IX and lack of tolerance in inbred mice

21 January 2018

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Mapping of genes that control the antibody response to human factor IX in mice

21 January 2018

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Heterogeneity of the immune response to adenovirus-mediated factor VIII gene therapy in different inbred hemophilic mouse strains

21 January 2018

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Healthy subjects produce both anti-factor VIII and specific anti-idiotypic antibodies

21 January 2018

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High-dose factor VIII inhibits factor VIII-specific memory B cells in hemophilia A with factor VIII inhibitors

21 January 2018

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Autoimmune anemia in macaques following erythropoietin gene therapy

21 January 2018

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Localization dose and time of antigens determine immune reactivity

21 January 2018

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Danger signals: SOS to the immune system

21 January 2018

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Dangerous liaisons: the role of "danger" signals in the immune response to gene therapy

21 January 2018

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Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion

21 January 2018

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Tolerance to factor VIII in a transgenic mouse expressing human factor VIII cDNA carrying an Arg(593) to Cys substitution.

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Genetic analysis of the antibody response to AAV2 and factor IX

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302881

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.GT.3302881

1 reference

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21 December 2019

1 reference