Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir (Q44859710)

6 December 2017

title

Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir (English)

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6 December 2017

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15

Stephen H Hughes

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6 December 2017

Steve Tuske

1

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6 December 2017

Stefan G Sarafianos

2

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6 December 2017

Arthur D Clark

3

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6 December 2017

Jianping Ding

4

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6 December 2017

Lisa K Naeger

5

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6 December 2017

Kirsten L White

6

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6 December 2017

Michael D Miller

7

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6 December 2017

Craig S Gibbs

8

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6 December 2017

Paul L Boyer

9

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6 December 2017

Patrick Clark

10

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6 December 2017

Gang Wang

11

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6 December 2017

Barbara L Gaffney

12

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6 December 2017

Roger A Jones

13

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6 December 2017

Donald M Jerina

14

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6 December 2017

Eddy Arnold

16

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6 December 2017

language of work or name

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25 April 2004

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Nature Structural & Molecular Biology

6 December 2017

published in

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6 December 2017

volume

11

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6 December 2017

issue

5

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6 December 2017

page(s)

469-474

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

6 December 2017

cites work

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Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids

21 January 2018

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The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.

21 January 2018

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YADD mutants of human immunodeficiency virus type 1 and Moloney murine leukemia virus reverse transcriptase are resistant to lamivudine triphosphate (3TCTP) in vitro.

21 January 2018

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Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

21 January 2018

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A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

21 January 2018

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Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase

21 January 2018

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The M184V mutation reduces the selective excision of zidovudine 5'-monophosphate (AZTMP) by the reverse transcriptase of human immunodeficiency virus type 1

21 January 2018

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Genotypic and phenotypic analyses of HIV-1 in antiretroviral-experienced patients treated with tenofovir DF.

21 January 2018

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Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

21 January 2018

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Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution

21 January 2018

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Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

21 January 2018

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Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

21 January 2018

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Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

21 January 2018

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Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.

21 January 2018

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Kinetic mechanism of DNA polymerase I(Klenow fragment): identification of a second conformational change and evaluation of the internal equilibrium constant

21 January 2018

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Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-Phosphonylmethoxypropyl)adenine

21 January 2018

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Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes

21 January 2018

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Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity

21 January 2018

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Mechanism-based suppression of dideoxynucleotide resistance by K65R human immunodeficiency virus reverse transcriptase using an alpha-boranophosphate nucleoside analogue.

21 January 2018

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Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision.

21 January 2018

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Phenotypic susceptibilities to tenofovir in a large panel of clinically derived human immunodeficiency virus type 1 isolates.

21 January 2018

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Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance

21 January 2018

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Trapping HIV-1 reverse transcriptase before and after translocation on DNA.

21 January 2018

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Improved strategies for postoligomerization synthesis of oligodeoxynucleotides bearing structurally defined adducts at the N2 position of deoxyguanosine.

21 January 2018

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Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

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Improved methods for building protein models in electron density maps and the location of errors in these models

21 January 2018

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Antiviral activities of 9-R-2-phosphonomethoxypropyl adenine (PMPA) and bis(isopropyloxymethylcarbonyl)PMPA against various drug-resistant human immunodeficiency virus strains

21 January 2018

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The K65R mutation confers increased DNA polymerase processivity to HIV-1 reverse transcriptase

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NSMB760

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6 December 2017

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