Pharmacogenetics of tipifarnib (R115777) transport and metabolism in cancer patients (Q44879826)

7 December 2017

Pharmacogenetics of tipifarnib (R115777) transport and metabolism in cancer patients (English)

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7 December 2017

1

Alex Sparreboom

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7 December 2017

4

Jaap Verweij

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7 December 2017

Sharon Marsh

2

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7 December 2017

Ron H J Mathijssen

series ordinal

3

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7 December 2017

Howard L McLeod

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5

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7 December 2017

language of work or name

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1 August 2004

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Investigational New Drugs

7 December 2017

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7 December 2017

22

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7 December 2017

3

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7 December 2017

285-289

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https://scigraph.springernature.com/pub.10.1023/b:drug.0000026254.97350.fe

7 December 2017

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cites work

C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation

1 reference

12 December 2020

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.

1 reference

12 December 2020

Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies

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12 December 2020

Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer.

1 reference

12 December 2020

Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populations

1 reference

12 December 2020

Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients

1 reference

12 December 2020

Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer

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12 December 2020

Irinotecan pathway genotype analysis to predict pharmacokinetics

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12 December 2020

Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line.

1 reference

12 December 2020

Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects.

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12 December 2020

Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.

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12 December 2020

Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial

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12 December 2020

Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer

1 reference

12 December 2020

Evaluation of accelerator mass spectrometry in a human mass balance and pharmacokinetic study-experience with 14C-labeled (R)-6-[amino(4- chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1- methyl-2(1H)-quinolinone (R115777), a far

1 reference

12 December 2020

Clinical trials referral resource. Current clinical trials of R115777 (Zarnestra).

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12 December 2020

The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome

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12 December 2020

Pharmacogenomics--drug disposition, drug targets, and side effects

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12 December 2020

10.1023/B:DRUG.0000026254.97350.FE

Identifiers

DOI

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Dimensions Publication ID

7 December 2017

1039729047

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Fatcat ID

release_qr542v72angpbjn7efkjqzjonq

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Fatcat

https://api.fatcat.wiki/v0/release/qr542v72angpbjn7efkjqzjonq

24 November 2022

mapped directly with Wikidata item

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