Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice (Q44880248)

7 December 2017

Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice (English)

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7 December 2017

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7 December 2017

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7 December 2017

Laura E Randle

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Dominic P Williams

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Dominic P Williams

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author name string

Christopher E P Goldring

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7 December 2017

Neil R Kitteringham

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7 December 2017

Robert Elsby

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7 December 2017

Yuri N Clement

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7 December 2017

Ken Itoh

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7 December 2017

Masayuki Yamamoto

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7 December 2017

B Kevin Park

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7 December 2017

language of work or name

English

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publication date

1 May 2004

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7 December 2017

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7 December 2017

39

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7 December 2017

5

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7 December 2017

1267-1276

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Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States

7 December 2017

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Reducing paracetamol overdoses

21 January 2018

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Differential enhancement of gamma-glutamyl transpeptidase and gamma-glutamylcysteine synthetase by tert-butylhydroquinone in rat lung epithelial L2 cells

21 January 2018

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The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

21 January 2018

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The electrophile counterattack response: protection against neoplasia and toxicity.

21 January 2018

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7 January 2021

Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention

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7 January 2021

Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene

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7 January 2021

Antioxidant response element

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7 January 2021

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein

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7 January 2021

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

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7 January 2021

Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2.

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7 January 2021

Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene

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7 January 2021

Nrf2 and c-Jun regulation of antioxidant response element (ARE)-mediated expression and induction of gamma-glutamylcysteine synthetase heavy subunit gene

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7 January 2021

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

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7 January 2021

Nrf2 is essential for protection against acute pulmonary injury in mice

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7 January 2021

High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

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7 January 2021

Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).

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7 January 2021

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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7 January 2021

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

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7 January 2021

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

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7 January 2021

Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

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7 January 2021

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

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7 January 2021

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

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7 January 2021

Cell culture model for acetaminophen-induced hepatocyte death in vivo

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7 January 2021

Role of CYP2E1 in the hepatotoxicity of acetaminophen

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7 January 2021

Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice

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7 January 2021

Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters.

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7 January 2021

Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection

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7 January 2021

The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity

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7 January 2021

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

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7 January 2021

Hepatocellular response to chemical stress in CD-1 mice: induction of early genes and gamma-glutamylcysteine synthetase

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7 January 2021

A microtiter plate assay for total glutathione and glutathione disulfide contents in cultured/isolated cells: performance study of a new miniaturized protocol

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7 January 2021

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

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7 January 2021

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

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7 January 2021

Alteration of transcriptional and post-transcriptional expression of gamma-glutamylcysteine synthetase by diethyl maleate.

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7 January 2021

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

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7 January 2021

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry

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7 January 2021

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

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7 January 2021

15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes

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7 January 2021

Thioredoxin as a molecular target of cyclopentenone prostaglandins.

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7 January 2021

Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products

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7 January 2021

Identifiers

DOI

10.1002/HEP.20183

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7 December 2017

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