Ex vivo zidovudine (AZT) treatment of CD34+ bone marrow progenitors causes decreased steady state mitochondrial DNA (mtDNA) and increased lactate production (Q44916797)

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English	Ex vivo zidovudine (AZT) treatment of CD34+ bone marrow progenitors causes decreased steady state mitochondrial DNA (mtDNA) and increased lactate production	scientific article

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scholarly article

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Europe PubMed Central

7 December 2017

Ex vivo zidovudine (AZT) treatment of CD34+ bone marrow progenitors causes decreased steady state mitochondrial DNA (mtDNA) and increased lactate production (English)

1 reference

Europe PubMed Central

7 December 2017

mitochondrial DNA

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1 reference

based on heuristic

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author name string

L D Lewis

1

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Europe PubMed Central

7 December 2017

S Amin

2

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Europe PubMed Central

7 December 2017

C I Civin

3

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Europe PubMed Central

7 December 2017

P S Lietman

4

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Europe PubMed Central

7 December 2017

language of work or name

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1 April 2004

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7 December 2017

Human & Experimental Toxicology

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Europe PubMed Central

7 December 2017

23

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Europe PubMed Central

7 December 2017

4

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Europe PubMed Central

7 December 2017

173-185

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Europe PubMed Central

7 December 2017

Long-term inhibition of human T-lymphotropic virus type III/lymphadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro

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Strategies for antiviral therapy in AIDS.

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Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex

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The safety and efficacy of zidovudine (AZT) in the treatment of subjects with mildly symptomatic human immunodeficiency virus type 1 (HIV) infection. A double-blind, placebo-controlled trial. The AIDS Clinical Trials Group

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21 January 2018

Prolonged zidovudine therapy in patients with AIDS and advanced AIDS-related complex. AZT Collaborative Working Group

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21 January 2018

The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

1 reference

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21 January 2018

Zidovudine in asymptomatic human immunodeficiency virus infection. A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter. The AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases

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Guidelines for using antiretroviral agents among HIV-infected adults and adolescents

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Toxicity of 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for normal human hematopoietic progenitor cells in vitro

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Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies

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Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

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Azidothymidine triphosphate is an inhibitor of both human immunodeficiency virus type 1 reverse transcriptase and DNA polymerase gamma

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The cellular location of dihydroorotate dehydrogenase: Relation to de novo biosynthesis of pyrimidines

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On auxotrophy for pyrimidines of respiration-deficient chick embryo cells.

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Intramitochondrial localization of delta-aminolaevulate synthetase and ferrochelatase in rat liver

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The mitochondrial localization of coproporphyrinogen III oxidase

1 reference

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Cell surface antigens on human marrow cells: dissection of hematopoietic development using monoclonal antibodies and multiparameter flow cytometry

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Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity

1 reference

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Effects of 2',3'-dideoxynucleosides on proliferation and differentiation of human pluripotent progenitors in liquid culture and their effects on mitochondrial DNA synthesis

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Heme deficiency in erythroid lineage causes differentiation arrest and cytoplasmic iron overload

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Ultrastructural changes associated with reduced mitochondrial DNA and impaired mitochondrial function in the presence of 2'3'-dideoxycytidine

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Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides

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Effect of anti-HIV 2'-beta-fluoro-2',3'-dideoxynucleoside analogs on the cellular content of mitochondrial DNA and on lactate production.

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A new syndrome of refractory sideroblastic anemia with vacuolization of marrow precursors and exocrine pancreatic dysfunction

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MITOCHONDRIAL DNA DELETION IN PEARSON'S MARROW/PANCREAS SYNDROME

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Pearson's marrow-pancreas syndrome. A multisystem mitochondrial disorder in infancy

1 reference

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Cytochrome c oxidase reaction improves histopathological assessment of zidovudine myopathy

1 reference

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Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria

1 reference

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21 January 2018

Mitochondrial myopathy caused by long-term zidovudine therapy

1 reference

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Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

1 reference

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Mitochondrial DNA depletion and morphologic changes in adipocytes associated with nucleoside reverse transcriptase inhibitor therapy

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Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice

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Acute hepatic failure and lactate acidosis associated with antiretroviral treatment for HIV.

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Identifiers

10.1191/0960327104HT437OA

1 reference

Europe PubMed Central

7 December 2017

1 reference

Europe PubMed Central

7 December 2017

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