Inverted signaling hierarchy between RAS and RAC in T-lymphocytes. (Q44927458)

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29 December 2019

title

Inverted signaling hierarchy between RAS and RAC in T-lymphocytes (English)

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29 December 2019

3

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29 December 2019

María-José Caloca

series ordinal

2

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29 December 2019

author name string

José L Zugaza

series ordinal

1

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29 December 2019

language of work or name

English

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publication date

1 July 2004

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29 December 2019

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29 December 2019

volume

23

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page(s)

5823-5833

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29 December 2019

issue

34

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207768

29 December 2019

exact match

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cites work

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Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

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Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation

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A Rac1 effector site controlling mitogenesis through superoxide production.

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Function and regulation of ras.

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Protein kinase D. A selective target for antigen receptors and a downstream target for protein kinase C in lymphocytes

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Analysis of the T-cell activation signaling pathway mediated by tyrosine kinases, protein kinase C, and Ras protein, which is modulated by intracellular cyclic AMP.

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Guanine nucleotide exchange factors: activators of Ras superfamily proteins

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Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

21 January 2018

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VAV proteins as signal integrators for multi-subunit immune-recognition receptors

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Effects of an aminosteroid inhibitor of phospholipase C-dependent processes on the TCR-mediated signal transduction pathway in human T cells

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Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C

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EGF-dependent translocation of green fluorescent protein-tagged PLC-gamma1 to the plasma membrane and endosomes.

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Deficiency of small GTPase Rac2 affects T cell activation

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Ras and Rho GTPases: a family reunion

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7 January 2021

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

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7 January 2021

The role of Rho GTPases in disease development

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Regulatory and signaling properties of the Vav family

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7 January 2021

Understanding Rho/Rac biology in T-cells using animal models

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7 January 2021

Exchange factors of the RasGRP family mediate Ras activation in the Golgi

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7 January 2021

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

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GTPases and T cell activation

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Membrane translocation of protein kinase Ctheta during T lymphocyte activation requires phospholipase C-gamma-generated diacylglycerol

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RasGRP is essential for mouse thymocyte differentiation and TCR signaling

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7 January 2021

RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs

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7 January 2021

Rho GTPases in cell biology

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7 January 2021

RasGRP: the missing link for Ras activation in thymocytes

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7 January 2021

RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase

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7 January 2021

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.

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7 January 2021

N-terminally truncated Vav induces the formation of depolymerization-resistant actin filaments in NIH 3T3 cells

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7 January 2021

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

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7 January 2021

Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1.

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7 January 2021

Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav

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7 January 2021

RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation.

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7 January 2021

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

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7 January 2021

Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3

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7 January 2021

A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation.

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7 January 2021

Vav modulation of the Ras/MEK/ERK signaling pathway plays a role in NFAT activation and CD69 up-regulation

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7 January 2021

A functional T-cell receptor signaling pathway is required for p95vav activity

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7 January 2021

Dbl family guanine nucleotide exchange factors

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7 January 2021

A genome-wide survey of RAS transformation targets

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207768

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15184873%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

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