Systemic delivery of DNA or siRNA mediated by linear polyethylenimine (L-PEI) does not induce an inflammatory response (Q44986711)

8 December 2017

Systemic delivery of DNA or siRNA mediated by linear polyethylenimine (L-PEI) does not induce an inflammatory response (English)

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8 December 2017

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Marie-Elise Bonnet

1

1 reference

PubMed ID

18709489

8 December 2017

Patrick Erbacher

series ordinal

2

1 reference

PubMed ID

18709489

8 December 2017

Anne-Laure Bolcato-Bellemin

series ordinal

3

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8 December 2017

16 August 2008

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8 December 2017

Pharmaceutical Research

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8 December 2017

25

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8 December 2017

12

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8 December 2017

2972-2982

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Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog

8 December 2017

1 reference

12 December 2020

Induction of gp120-specific protective immune responses by genetic vaccination with linear polyethylenimine-plasmid complex

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12 December 2020

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

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12 December 2020

Inhibition of influenza virus production in virus-infected mice by RNA interference

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12 December 2020

Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments

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12 December 2020

Regulatory sequences of H19 and IGF2 genes in DNA-based therapy of colorectal rat liver metastases

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12 December 2020

Sticky overhangs enhance siRNA-mediated gene silencing

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12 December 2020

Lack of interferon response in animals to naked siRNAs

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12 December 2020

A comparison of linear and branched polyethylenimine (PEI) with DCChol/DOPE liposomes for gene delivery to epithelial cells in vitro and in vivo

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12 December 2020

Gene silencing through RNA interference (RNAi) in vivo: strategies based on the direct application of siRNAs

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12 December 2020

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12 December 2020

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide

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12 December 2020

No induction of anti-viral responses in human cell lines HeLa and MCF-7 when transfecting with siRNA or siLNA.

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12 December 2020

Evaluation of proinflammatory cytokine production induced by linear and branched polyethylenimine/plasmid DNA complexes in mice

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12 December 2020

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

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12 December 2020

Suppression of immunostimulatory siRNA-driven innate immune activation by 2'-modified RNAs.

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12 December 2020

Carbon tetrachloride hepatotoxicity

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12 December 2020

Pulmonary cytokine responses associated with PEI-DNA aerosol gene therapy

1 reference

12 December 2020

CpG motifs: the active ingredient in bacterial extracts?

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12 December 2020

Polycation-based DNA complexes for tumor-targeted gene delivery in vivo

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12 December 2020

DermaVir: a novel topical vaccine for HIV/AIDS.

1 reference

12 December 2020

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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12 December 2020

DNA sequences in cationic lipid:pDNA-mediated systemic toxicities

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12 December 2020

Prolonged organ retention and safety of plasmid DNA administered in polyethylenimine complexes

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12 December 2020

Contribution of plasmid DNA to hepatotoxicity after systemic administration of lipoplexes

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12 December 2020

Early enzyme release from myocardial cells is not due to irreversible cell damage

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12 December 2020

CpG motifs in bacterial DNA trigger direct B-cell activation

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12 December 2020

In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers

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12 December 2020

The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes

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12 December 2020

Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs

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12 December 2020

Mechanisms of cell damage and enzyme release.

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12 December 2020

Induction of the interferon response by siRNA is cell type- and duplex length-dependent

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12 December 2020

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

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12 December 2020

Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors

1 reference

12 December 2020

Bacterial DNA is implicated in the inflammatory response to delivery of DNA/DOTAP to mouse lungs

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12 December 2020

Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo

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12 December 2020

Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application

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12 December 2020

Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system

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12 December 2020

Clinical pathology approaches to hepatic injury

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12 December 2020

Hepatoprotective effect of Himoliv, a polyherbal formulation in rats.

1 reference

12 December 2020

RNA interference and innate immunity

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12 December 2020

A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy

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12 December 2020

LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth

1 reference

12 December 2020

Noninvasive imaging of cationic lipid-mediated delivery of optical and PET reporter genes in living mice

1 reference

12 December 2020

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

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12 December 2020

Comparison between cationic polymers and lipids in mediating systemic gene delivery to the lungs

1 reference

12 December 2020

RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

1 reference

12 December 2020

The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo

1 reference

12 December 2020

Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector

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12 December 2020

A hybrid CMV-H1 construct improves efficiency of PEI-delivered shRNA in the mouse brain.

1 reference

12 December 2020

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

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12 December 2020

Transfection of multiple pulmonary cell types following intravenous injection of PEI-DNA in normal and CFTR mutant mice

1 reference

12 December 2020

Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid:plasmid DNA complexes in mice

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12 December 2020

Induction of potent human immunodeficiency virus type 1-specific T-cell-restricted immunity by genetically modified dendritic cells

1 reference

12 December 2020

Sequential injection of cationic liposome and plasmid DNA effectively transfects the lung with minimal inflammatory toxicity

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12 December 2020

Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid: cationic lipid complexes

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12 December 2020

Exogenous siRNA mediates sequence-independent gene suppression by signaling through toll-like receptor 3.

1 reference

12 December 2020

Immunotherapeutic uses of CpG oligodeoxynucleotides

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12 December 2020

Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling

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12 December 2020

Control of viral rebound through therapeutic immunization with DermaVir

1 reference

12 December 2020

Polyethylenimine-based intravenous delivery of transgenes to mouse lung.

1 reference

12 December 2020

Tissue release of cardiac markers: from physiology to clinical applications

1 reference

12 December 2020

Ribonuclease H. An Enzyme Degrading the RNA Moiety of DNA-RNA Hybrids

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12 December 2020

2. Cytokines and chemokines

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12 December 2020

In vivo gene delivery in the retina using polyethylenimine

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12 December 2020

Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse

1 reference

12 December 2020

Development of non-viral vectors for systemic gene delivery

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12 December 2020

Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery.

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12 December 2020

Biodistribution and tissue expression kinetics of plasmid DNA complexed with polyethylenimines of different molecular weight and structure

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12 December 2020

Antitumor effect of in vivo somatostatin receptor subtype 2 gene transfer in primary and metastatic pancreatic cancer models

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12 December 2020

Cationic compounds used in lipoplexes and polyplexes for gene delivery

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12 December 2020

Side-effects of a systemic injection of linear polyethylenimine-DNA complexes

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12 December 2020

RNA interference-mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoral effects in glioblastoma xenografts.

1 reference

12 December 2020

Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis

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12 December 2020

Optimized galenics improve in vitro gene transfer with cationic molecules up to 1000-fold.

1 reference

12 December 2020

Jet nebulization of PEI/DNA polyplexes: physical stability and in vitro gene delivery efficiency

1 reference

12 December 2020

10.1007/S11095-008-9693-1

Identifiers

DOI

1 reference

8 December 2017

1 reference

PubMed ID

18709489