Prevention of Alzheimer's disease-associated Abeta aggregation by rationally designed nonpeptidic beta-sheet ligands (Q45025078)

8 December 2017

title

Prevention of Alzheimer's disease-associated Abeta aggregation by rationally designed nonpeptidic beta-sheet ligands (English)

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8 December 2017

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Luitgard Nagel-Steger

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8 December 2017

Sophie Feuerstein

3

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author name string

Petra Rzepecki

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8 December 2017

Uwe Linne

4

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Oliver Molt

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Reza Zadmard

6

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Katja Aschermann

7

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Markus Wehner

8

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8 December 2017

Thomas Schrader

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Detlev Riesner

10

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8 December 2017

language of work or name

English

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publication date

20 August 2004

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Journal of Biological Chemistry

8 December 2017

published in

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volume

279

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8 December 2017

issue

46

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8 December 2017

page(s)

47497-47505

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The prionoses and other conformational disorders

8 December 2017

cites work

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21 January 2018

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Therapeutic approaches to protein-misfolding diseases

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Therapeutic strategies for human amyloid diseases

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Perspectives of pharmacotherapy in Alzheimer's disease

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Plaque busters: strategies to inhibit amyloid formation in Alzheimer's disease

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis

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Alzheimer's disease: genotypes, phenotypes, and treatments

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Propagating structure of Alzheimer's beta-amyloid(10-35) is parallel beta-sheet with residues in exact register

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De novo amyloid proteins from designed combinatorial libraries

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Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease

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Inhibition of Alzheimer beta-fibrillogenesis by melatonin

21 January 2018

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Inhibition of beta-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library

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Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

21 January 2018

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Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro

21 January 2018

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In vitro fibrillogenesis of the amyloid beta 1-42 peptide: cholesterol potentiation and aspirin inhibition

21 January 2018

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Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy

21 January 2018

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Structure-function relationships for inhibitors of beta-amyloid toxicity containing the recognition sequence KLVFF.

21 January 2018

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Inhibitors of fibril formation and cytotoxicity of beta-amyloid peptide composed of KLVFF recognition element and flexible hydrophilic disrupting element.

21 January 2018

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Inhibition of beta-amyloid(40) fibrillogenesis and disassembly of beta-amyloid(40) fibrils by short beta-amyloid congeners containing N-methyl amino acids at alternate residues

21 January 2018

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Probing the role of backbone hydrogen bonding in beta-amyloid fibrils with inhibitor peptides containing ester bonds at alternate positions.

21 January 2018

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Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

21 January 2018

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Two new beta-strand mimics

21 January 2018

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Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy

21 January 2018

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Interaction between synthetic amyloid-beta-peptide (1-40) and its aggregation inhibitors studied by electrospray ionization mass spectrometry

21 January 2018

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Interaction of ferrocenoyl-dipeptides with 3-aminopyrazole derivatives: beta-sheet models? A synthetic, spectroscopic, structural, and electrochemical study

21 January 2018

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Controlling polymerization of beta-amyloid and prion-derived peptides with synthetic small molecule ligands.

21 January 2018

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

21 January 2018

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

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Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M405914200

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8 December 2017

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