Site-saturation mutagenesis of Tyr-105 reveals its importance in substrate stabilization and discrimination in TEM-1 beta-lactamase (Q45028104)

8 December 2017

Site-saturation mutagenesis of Tyr-105 reveals its importance in substrate stabilization and discrimination in TEM-1 beta-lactamase (English)

1 reference

8 December 2017

3

Joelle N Pelletier

1 reference

8 December 2017

Nicolas Doucet

1

1 reference

PubMed ID

15326193

8 December 2017

Pierre-Yves De Wals

series ordinal

2

1 reference

PubMed ID

15326193

8 December 2017

language of work or name

English

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publication date

23 August 2004

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Journal of Biological Chemistry

8 December 2017

9

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based on heuristic

inferred from page(s)

published in

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8 December 2017

279

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8 December 2017

46295-46303

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8 December 2017

44

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Predicting the emergence of antibiotic resistance by directed evolution and structural analysis

8 December 2017

1 reference

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Contribution of mutant analysis to the understanding of enzyme catalysis: the case of class A beta-lactamases

21 January 2018

1 reference

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Catalytic properties of class A beta-lactamases: efficiency and diversity

21 January 2018

1 reference

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Extended-spectrum and inhibitor-resistant TEM-type beta-lactamases: mutations, specificity, and three-dimensional structure

21 January 2018

1 reference

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Class A beta-lactamases--enzyme-inhibitor interactions and resistance

21 January 2018

1 reference

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An ultrahigh resolution structure of TEM-1 beta-lactamase suggests a role for Glu166 as the general base in acylation

21 January 2018

1 reference

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Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution

21 January 2018

1 reference

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The high resolution crystal structure for class A beta-lactamase PER-1 reveals the bases for its increase in breadth of activity

21 January 2018

1 reference

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Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin

21 January 2018

1 reference

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Molecular dynamics at the root of expansion of function in the M69L inhibitor-resistant TEM beta-lactamase from Escherichia coli

21 January 2018

1 reference

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Insights into the acylation mechanism of class A beta-lactamases from molecular dynamics simulations of the TEM-1 enzyme complexed with benzylpenicillin

21 January 2018

1 reference

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Role of protein flexibility in enzymatic catalysis: quantum mechanical-molecular mechanical study of the deacylation reaction in class A beta-lactamases

21 January 2018

1 reference

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Effects of site-specific mutagenesis of tyrosine 105 in a class A beta-lactamase

21 January 2018

1 reference

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Structure of a phosphonate-inhibited beta-lactamase. An analog of the tetrahedral transition state/intermediate of beta-lactam hydrolysis

21 January 2018

1 reference

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Recognition and resistance in TEM beta-lactamase

21 January 2018

1 reference

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A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex.

21 January 2018

1 reference

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21 January 2018

b-Lactamase inhibitors

1 reference

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Amino acid sequence determinants of beta-lactamase structure and activity

21 January 2018

1 reference

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Site-directed mutagenesis by overlap extension using the polymerase chain reaction

21 January 2018

1 reference

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Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime

21 January 2018

1 reference

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Role of residues 104, 164, 166, 238 and 240 in the substrate profile of PER-1 beta-lactamase hydrolysing third-generation cephalosporins

21 January 2018

1 reference

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Crystal structure of Escherichia coli TEM1 beta-lactamase at 1.8 A resolution

21 January 2018

1 reference

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Specific chemical modification of the readily nitrated tyrosine of the RTEM beta-lactamase and of bacillus cereus beta-lactamase I. The role of the tyrosine in beta-lactamase catalysis

21 January 2018

1 reference

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Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,)

21 January 2018

1 reference

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Beta-lactamase of Bacillus licheniformis 749/C at 2 A resolution

21 January 2018

1 reference

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The crystal structure of the beta-lactamase of Streptomyces albus G at 0.3 nm resolution

21 January 2018

1 reference

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X-ray analysis of the NMC-A beta-lactamase at 1.64-A resolution, a class A carbapenemase with broad substrate specificity

21 January 2018

1 reference

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A standard numbering scheme for the class A beta-lactamases

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M407606200

1 reference

8 December 2017

1 reference

PubMed ID

15326193