Role of Lys-32 residues in R67 dihydrofolate reductase probed by asymmetric mutations (Q45034283)

8 December 2017

title

Role of Lys-32 residues in R67 dihydrofolate reductase probed by asymmetric mutations (English)

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8 December 2017

5

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8 December 2017

Stephanie N Hicks

1

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8 December 2017

R Derike Smiley

series ordinal

2

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8 December 2017

Lori G Stinnett

series ordinal

3

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8 December 2017

Kenneth H Minor

series ordinal

4

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8 December 2017

language of work or name

English

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publication date

27 August 2004

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Journal of Biological Chemistry

8 December 2017

published in

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8 December 2017

volume

279

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8 December 2017

issue

45

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8 December 2017

page(s)

46995-47002

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A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site

8 December 2017

cites work

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Unusual binding stoichiometries and cooperativity are observed during binary and ternary complex formation in the single active pore of R67 dihydrofolate reductase, a D2 symmetric protein

21 January 2018

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One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme

21 January 2018

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Role of S65, Q67, I68, and Y69 residues in homotetrameric R67 dihydrofolate reductase

21 January 2018

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Breaking symmetry: mutations engineered into R67 dihydrofolate reductase, a D2 symmetric homotetramer possessing a single active site pore

21 January 2018

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Role of ionic interactions in ligand binding and catalysis of R67 dihydrofolate reductase

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Defining the binding site of homotetrameric R67 dihydrofolate reductase and correlating binding enthalpy with catalysis

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21 January 2018

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NMR studies of the interaction of a type II dihydrofolate reductase with pyridine nucleotides reveal unexpected phosphatase and reductase activity

21 January 2018

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Titration of histidine 62 in R67 dihydrofolate reductase is linked to a tetramer<-->two-dimer equilibrium.

21 January 2018

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Interligand Overhauser effects in type II dihydrofolate reductase

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21 January 2018

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21 January 2018

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Characterization and stereochemistry of cofactor oxidation by a type II dihydrofolate reductase.

21 January 2018

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Conformation of NADP+ bound to a type II dihydrofolate reductase.

21 January 2018

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"Catch 222," the effects of symmetry on ligand binding and catalysis in R67 dihydrofolate reductase as determined by mutations at Tyr-69.

21 January 2018

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Redesigning the Quaternary Structure of R67 Dihydrofolate Reductase

21 January 2018

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A glutamine 67--> histidine mutation in homotetrameric R67 dihydrofolate reductase results in four mutations per single active site pore and causes substantial substrate and cofactor inhibition

21 January 2018

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Dihydrofolate reductase from Escherichia coli: probing the role of aspartate-27 and phenylalanine-137 in enzyme conformation and the binding of NADPH

21 January 2018

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Crystalline Dihydropteroylglutamic Acid

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M404484200

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release_ngihqgc7nbe7vcpfqtpqk3d4d4

8 December 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ngihqgc7nbe7vcpfqtpqk3d4d4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference