Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. (Q45050765)

8 December 2017

Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species (English)

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12 May 2020

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reactive oxygen species

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3

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Anatoly Starkov

1

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M Flint Beal

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author name string

Gary Fiskum

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Beverly J Lorenzo

4

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Susan E Browne

5

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Mulchand S Patel

6

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language of work or name

English

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publication date

1 September 2004

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8 December 2017

Journal of Neuroscience

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volume

24

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page(s)

7779-7788

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issue

36

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Mitochondria in neurodegeneration: bioenergetic function in cell life and death

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cites work

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12 December 2020

Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases

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12 December 2020

Comparisons of coenzyme Q bound to mitochondrial membrane proteins among different mammalian species

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12 December 2020

Quantitative alpha-ketoglutarate dehydrogenase activity staining in brain sections and in cultured cells.

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Mitochondria and neuronal survival

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12 December 2020

Effect of coenzyme Q(10) and alpha-tocopherol content of mitochondria on the production of superoxide anion radicals

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12 December 2020

Mitochondrial oxygen radical generation and leak: sites of production in states 4 and 3, organ specificity, and relation to aging and longevity

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The alpha-ketoglutarate dehydrogenase complex

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12 December 2020

Mitochondrial participation in ischemic and traumatic neural cell death

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12 December 2020

Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart.

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12 December 2020

Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress.

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12 December 2020

Myxothiazol induces H(2)O(2) production from mitochondrial respiratory chain

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12 December 2020

DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria

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12 December 2020

The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology

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12 December 2020

Selective loss of KGDHC-enriched neurons in Alzheimer temporal cortex: does mitochondrial variation contribute to selective vulnerability?

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12 December 2020

Generation of reactive oxygen species by the mitochondrial electron transport chain

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12 December 2020

Oxidative stress increases internal calcium stores and reduces a key mitochondrial enzyme

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12 December 2020

Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.

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12 December 2020

Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax.

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Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion

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12 December 2020

Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species

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12 December 2020

Quantitative relationship between inhibition of respiratory complexes and formation of reactive oxygen species in isolated nerve terminals.

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12 December 2020

In situ assay of the intramitochondrial enzymes: use of alamethicin for permeabilization of mitochondria

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12 December 2020

2-Oxo acid dehydrogenase complexes in redox regulation

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12 December 2020

Cyclosporin A-insensitive permeability transition in brain mitochondria: inhibition by 2-aminoethoxydiphenyl borate

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Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain

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12 December 2020

Production of reactive oxygen species by mitochondria: central role of complex III.

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12 December 2020

Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state.

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12 December 2020

Relation of superoxide generation and lipid peroxidation to the inhibition of NADH-Q oxidoreductase by rotenone, piericidin A, and MPP+

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12 December 2020

Limitations of the Phenazine Methosulphate Assay for Succinic and Related Dehydrogenases

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12 December 2020

Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria.

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12 December 2020

Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase.

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12 December 2020

Effect of ammonia on mitochondrial and cytosolic NADH and NADPH systems in isolated rat liver cells

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12 December 2020

The use of acetylated ferricytochrome C for the detection of superoxide radicals produced in biological membranes

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12 December 2020

Ion pair formation in pig heart lipoamide dehydrogenase: rationalization of pH profiles for reactivity of oxidized enzyme with dihydrolipoamide and 2-electron-reduced enzyme with lipoamide and iodoacetamide

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12 December 2020

A Kinetic Study of the α-Keto Acid Dehydrogenase Complexes from Pig Heart Mitochondria1

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12 December 2020

Studies on the mechanism and kinetics of the 2-oxoglutarate dehydrogenase system from pig heart

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12 December 2020

Kinetic characterization of the pyruvate and oxoglutarate dehydrogenase complexes from human heart.

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12 December 2020

Rapid isolation of metabolically active mitochondria from rat brain and subregions using Percoll density gradient centrifugation

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Structure-function relationships in dihydrolipoamide acyltransferases

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Molecular biology and biochemistry of pyruvate dehydrogenase complexes.

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Localization of the alpha-oxoacid dehydrogenase multienzyme complexes within the mitochondrion

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Regulation of citric acid cycle by calcium

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Supramolecular organization of tricarboxylic acid cycle enzymes

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Generation of hydrogen peroxide by brain mitochondria: the effect of reoxygenation following postdecapitative ischemia

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12 December 2020

Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

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Cerebral ischemia and reperfusion: prevention of brain mitochondrial injury by lidoflazine.

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Generation of H2O2 in brain mitochondria.

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12 December 2020

Contribution of different enzymes to flavoprotein fluorescence of isolated rat liver mitochondria

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Enzyme-catalyzed free radical reactions with nicotinamide adenine nucleotides. II. Lactate dehydrogenase-catalyzed oxidation of reduced nicotinamide adenine dinucleotide by superoxide radicals generated by xanthine oxidase

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Oxygen radicals and hydrogen peroxide in rat brain mitochondria.

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12 December 2020

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

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Properties and subunit composition of the pig heart 2-oxoglutarate dehydrogenase

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Ammonia formation in isolated rat liver mitochondria

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alpha-Ketoglutarate dehydrogenase complex may be heterogeneous in quaternary structure

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Complex I binds several mitochondrial NAD-coupled dehydrogenases.

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Magnetic circular dichroism studies on the active-site flavin of lipoamide dehydrogenase

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Glyceraldehyde-3-phosphate dehydrogenase-catalyzed chain oxidation of reduced nicotinamide adenine dinucleotide by perhydroxyl radicals

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12 December 2020

Transient and Steady-State Kinetics of the Oxidation of Scopoletin by Horseradish Peroxidase Compounds I, II and III in the Presence of NADH

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12 December 2020

Ca(2+)-induced mitochondrial membrane permeabilization: role of coenzyme Q redox state.

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12 December 2020

Distribution of the alpha-ketoglutarate dehydrogenase complex in rat brain

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Isolated cerebral and cerebellar mitochondria produce free radicals when exposed to elevated CA2+ and Na+: implications for neurodegeneration

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Activation of molecular oxygen by flavins and flavoproteins.

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Quantification of the content of fluorescent flavoproteins in mitochondria from liver, kidney cortex, skeletal muscle, and brain.

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Opening of the mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca2+ is dependent on mitochondrial-generated reactive oxygen species.

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12 December 2020

Dependence of H2O2 formation by rat heart mitochondria on substrate availability and donor age.

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12 December 2020

Superoxide production by the mitochondrial respiratory chain

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12 December 2020

Mitochondrial ubiquinone homologues, superoxide radical generation, and longevity in different mammalian species

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12 December 2020

A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidases

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12 December 2020

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

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12 December 2020

Targeted disruption of the murine dihydrolipoamide dehydrogenase gene (Dld) results in perigastrulation lethality

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12 December 2020

Substrate and site specificity of hydrogen peroxide generation in mouse mitochondria.

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12 December 2020

The thiol-specific antioxidant enzyme prevents mitochondrial permeability transition. Evidence for the participation of reactive oxygen species in this mechanism

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12 December 2020

The antioxidant defences of brain mitochondria during short-term forebrain ischemia and recirculation in the rat.

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12 December 2020

Ca2+-stimulated mitochondrial reactive oxygen species generation and permeability transition are inhibited by dibucaine or Mg2+.

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12 December 2020

Interaction of alpha-phenyl-N-tert-butyl nitrone and alternative electron acceptors with complex I indicates a substrate reduction site upstream from the rotenone binding site.

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12 December 2020

Generation of superoxide anion by succinate-cytochrome c reductase from bovine heart mitochondria

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12 December 2020

10.1523/JNEUROSCI.1899-04.2004

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729932&resulttype=core&format=json

12 May 2020

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12 May 2020

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