Down-regulation of FLIP sensitizes rheumatoid synovial fibroblasts to Fas-mediated apoptosis. (Q45085314)

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3 January 2020

title

Down-regulation of FLIP sensitizes rheumatoid synovial fibroblasts to Fas-mediated apoptosis (English)

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3 January 2020

3

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3 January 2020

author name string

Guillermo Palao

1

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3 January 2020

Begoña Santiago

2

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3 January 2020

Mónica Payá

4

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3 January 2020

Juan C Ramirez

5

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3 January 2020

José L Pablos

6

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publication date

1 September 2004

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3 January 2020

published in

Arthritis and Rheumatism

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3 January 2020

volume

50

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3 January 2020

issue

9

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3 January 2020

page(s)

2803-2810

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Apoptosis in rheumatoid arthritis

3 January 2020

cites work

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Death receptors couple to both cell proliferation and apoptosis

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Death receptors: signaling and modulation

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FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis

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Inhibition of death receptor signals by cellular FLIP

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FLICE-inhibitory protein expression during macrophage differentiation confers resistance to fas-mediated apoptosis

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Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing

21 January 2018

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Rheumatoid arthritis synovial macrophages express the Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein and are refractory to Fas-mediated apoptosis

21 January 2018

1 reference

Two CD95 (APO-1/Fas) signaling pathways

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Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

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c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

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Low levels of apoptosis and high FLIP expression in early rheumatoid arthritis synovium

21 January 2018

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NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

21 January 2018

1 reference

NF-kappaB signals induce the expression of c-FLIP.

21 January 2018

1 reference

Gene therapy that inhibits nuclear translocation of nuclear factor kappaB results in tumor necrosis factor alpha-induced apoptosis of human synovial fibroblasts

21 January 2018

1 reference

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

21 January 2018

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Non-apoptotic signaling pathways activated by soluble Fas ligand in serum-starved human fibroblasts. Mitogen-activated protein kinases and NF-kappaB-dependent gene expression.

21 January 2018

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Non-apoptotic Fas signaling.

21 January 2018

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NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint

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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

21 January 2018

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