Substrate-assisted catalysis of peptide bond formation by the ribosome (Q45099790)

9 December 2017

title

Substrate-assisted catalysis of peptide bond formation by the ribosome (English)

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9 December 2017

3

Silke Dorner

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9 December 2017

Joshua S Weinger

1

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9 December 2017

K Mark Parnell

series ordinal

2

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9 December 2017

Rachel Green

series ordinal

4

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9 December 2017

Scott A Strobel

series ordinal

5

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9 December 2017

publication date

10 October 2004

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Nature Structural & Molecular Biology

9 December 2017

published in

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9 December 2017

volume

11

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9 December 2017

issue

11

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9 December 2017

page(s)

1101-1106

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https://scigraph.springernature.com/pub.10.1038/nsmb841

9 December 2017

exact match

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cites work

Peptide bond formation on the ribosome: structure and mechanism

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The structural basis of ribosome activity in peptide bond synthesis

21 January 2018

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Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide

21 January 2018

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The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release

21 January 2018

1 reference

The G2447A mutation does not affect ionization of a ribosomal group taking part in peptide bond formation

21 January 2018

1 reference

Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit

21 January 2018

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The ribosome as an entropy trap

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Isomeric phenylalanyl-tRNAs. Position of the aminoacyl moiety during protein biosynthesis

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Mononucleotide derivatives as ribosomal P-site substrates reveal an important contribution of the 2'-OH to activity

21 January 2018

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SOME OBSERVATIONS ON THE MECHANISM OF THE ACYLATION PROCESS IN PROTEIN SYNTHESIS

21 January 2018

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Structural insights into peptide bond formation

21 January 2018

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Catalysis of amide synthesis by RNA phosphodiester and hydroxyl groups

21 January 2018

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Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome.

21 January 2018

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Catalysis of ribosomal translocation by sparsomycin

21 January 2018

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Contributions of 2'-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA.

21 January 2018

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The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction

21 January 2018

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Metal ion interaction with cosubstrate in self-splicing of group I introns

21 January 2018

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Probing the role of metal ions in RNA catalysis: kinetic and thermodynamic characterization of a metal ion interaction with the 2'-moiety of the guanosine nucleophile in the Tetrahymena group I ribozyme

21 January 2018

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Crystal structure of a self-splicing group I intron with both exons

21 January 2018

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Ribozyme inhibitors: deoxyguanosine and dideoxyguanosine are competitive inhibitors of self-splicing of the Tetrahymena ribosomal ribonucleic acid precursor

21 January 2018

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General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme

21 January 2018

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Imidazole rescue of a cytosine mutation in a self-cleaving ribozyme

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Catalytic roles for proton transfer and protonation in ribozymes

21 January 2018

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Substrate-assisted catalysis: molecular basis and biological significance

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Translation: in retrospect and prospect

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Structural constraints in the HIV-1 reverse transcriptase-primer/template complex for the initiation of DNA synthesis from primer tRNALys3.

21 January 2018

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Crystal structure at 1.2 A resolution and active site mapping of Escherichia coli peptidyl-tRNA hydrolase

21 January 2018

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Sites of interaction of the CCA end of peptidyl-tRNA with 23S rRNA.

21 January 2018

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Ground-State Properties of Nucleic Acid Constituents Studied by Density Functional Calculations. 3. Role of Sugar Puckering and Base Orientation on the Energetics and Geometry of 2‘-Deoxyribonucleosides and Ribonucleosides

21 January 2018

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A single adenosine with a neutral pKa in the ribosomal peptidyl transferase center

21 January 2018

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Activity of the 2' and 3' isomers of aminoacyl transfer ribonucleic acid in the in vitro peptide elongation on Escherichia coli ribosomes

31 March 2020

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Inhibition of ribosomal translocation by peptidyl transfer ribonucleic acid analogues

31 March 2020

1 reference

Donor site of ribosomal peptidyltransferase: investigation of substrate specificity using 2'(3')-O-(N-acylaminoacyl)dinucleoside phosphates as models of the 3' terminus of N-acylaminoacyl transfer ribonucleic acid

31 March 2020

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A possible mechanism of peptide bond formation on ribosome without mediation of peptidyl transferase

31 March 2020

1 reference

A hydrogen-bonding triad stabilizes the chemical transition state of a group I ribozyme

31 March 2020

1 reference

Binding of guanosine and 3' splice site analogues to a group I ribozyme: interactions with functional groups of guanosine and with additional nucleotides

31 March 2020

1 reference

Engineering enzyme specificity by "substrate-assisted catalysis"

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB841

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Dimensions Publication ID

9 December 2017

1007032380

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