AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study (Q45127753)

9 December 2017

AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study (English)

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9 December 2017

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Kristiina Tyynelä

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Gillian Langford

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Arto Immonen

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Matti Vapalahti

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Heleena Hurskainen

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Anu Sandmair

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Ritva Vanninen

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Neil Murray

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1 November 2004

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967-972

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In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

9 December 2017

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Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells.

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1H MRS detects polyunsaturated fatty acid accumulation during gene therapy of glioma: implications for the in vivo detection of apoptosis.

7 January 2021

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Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses

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Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions

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Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy in BT4C rat glioma model

7 January 2021

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Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo

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Adenovirus-mediated gene therapy of experimental gliomas

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Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses

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A Phase I/II Study of Herpes Simplex Virus Type 1 Thymidine Kinase “Suicide” Gene Therapy for Recurrent Glioblastoma

7 January 2021

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A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group

7 January 2021

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A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme.

7 January 2021

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Cancer gene therapy — current status in the clinics

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Treatment of advanced CNS malignancies with the recombinant adenovirus H5.010RSVTK: a phase I trial.

7 January 2021

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Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors.

7 January 2021

1 reference

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Treatment of relapsed malignant glioma with an adenoviral vector containing the herpes simplex thymidine kinase gene followed by ganciclovir

7 January 2021

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Clinical trials of adenoviral-mediated suicide gene therapy of malignant gliomas

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Sensitivity and reproducibility in adenoviral infectious titer determination

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10.1016/J.YMTHE.2004.08.002

7 January 2021

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9 December 2017

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