Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death. (Q45249955)

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8 January 2020

title

Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death (English)

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8 January 2020

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Mark Wogulis

1

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8 January 2020

Sarah Wright

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8 January 2020

Damian Cunningham

3

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8 January 2020

Tamie Chilcote

4

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Kyle Powell

5

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8 January 2020

Russell E Rydel

6

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language of work or name

English

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publication date

1 February 2005

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8 January 2020

published in

Journal of Neuroscience

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8 January 2020

volume

25

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8 January 2020

page(s)

1071-1080

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8 January 2020

issue

5

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Inhibitors of V-type ATPases, bafilomycin A1 and concanamycin A, protect against beta-amyloid-mediated effects on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction.

8 January 2020

cites work

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beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.

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Astrocytes contribute to neuronal impairment in beta A toxicity increasing apoptosis in rat hippocampal neurons.

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CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis

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The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

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Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

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Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

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Effect of beta-amyloid on endothelial cells: lack of direct toxicity, enhancement of MTT-induced cell death and intracellular accumulation

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Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

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Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.

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beta-Amyloid peptide in vitro toxicity: lot-to-lot variability

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Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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Self-assembly of Abeta(1-42) into globular neurotoxins.

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Folding proteins in fatal ways

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Astrocyte modulation of in vitro beta-amyloid neurotoxicity.

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Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

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12 December 2020

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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12 December 2020

Aggregation state and neurotoxic properties of Alzheimer beta-amyloid peptide

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12 December 2020

The intracellular component of cellular 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) reduction is specifically inhibited by beta-amyloid peptides.

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12 December 2020

Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death

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12 December 2020

Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro

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12 December 2020

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

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12 December 2020

Mechanisms of neuronal degeneration in Alzheimer's disease

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12 December 2020

Beta-amyloid-induced cell toxicity: enhancement of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide-dependent cell death.

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12 December 2020

First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro.

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12 December 2020

beta-Amyloid-mediated inhibition of redox activity (MTT reduction) is not an indicator of astroglial degeneration.

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12 December 2020

All-D-enantiomers of beta-amyloid exhibit similar biological properties to all-L-beta-amyloids.

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12 December 2020

Stopped-flow kinetics reveal multiple phases of thioflavin T binding to Alzheimer beta (1-40) amyloid fibrils.

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12 December 2020

The toxicity of the Alzheimer's beta-amyloid peptide correlates with a distinct fiber morphology.

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12 December 2020

Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction.

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12 December 2020

Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

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12 December 2020

Soluble amyloid Abeta-(1-40) exists as a stable dimer at low concentrations

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12 December 2020

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

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12 December 2020

Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction.

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12 December 2020

Pathologic amyloid beta-protein cell surface fibril assembly on cultured human cerebrovascular smooth muscle cells

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12 December 2020

Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins

1 reference

12 December 2020

10.1523/JNEUROSCI.2381-04.2005

Identifiers

DOI

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