Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates (Q45305166)

11 December 2017

Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates (English)

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11 December 2017

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Nicole Déglon

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Philippe Hantraye

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object named as

Philippe Hantraye

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Stéphane Palfi

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11 December 2017

Caroline Jan

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11 December 2017

Masahiro Shin

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11 December 2017

Françoise Condé

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Xiao-Jiang Li

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Patrick Aebischer

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1 May 2007

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11 December 2017

1444-1451

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

11 December 2017

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Huntingtin-protein interactions and the pathogenesis of Huntington's disease

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Mouse models of Huntington's disease

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

The MPTP model: versatile contributions to the treatment of idiopathic Parkinson's disease

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Cognitive deficits precede motor deficits in a slowly progressing model of parkinsonism in the monkey.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of Huntington's disease

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Functional integration of striatal allografts in a primate model of Huntington's disease.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

A primate model of Huntington's disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Selective putaminal excitotoxic lesions in non-human primates model the movement disorder of Huntington disease.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Lentiviral gene transfer to the nonhuman primate brain

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Presymptomatic and early detection in Huntington's disease

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Tourettism associated with Huntington's disease

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Tourettism as clinical presentation of Huntington's disease with onset in childhood

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Transgenic rat model of Huntington's disease

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Behavioural disorders induced by external globus pallidus dysfunction in primates II. Anatomical study

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Behavioural disorders induced by external globus pallidus dysfunction in primates: I. Behavioural study

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Experimental hemichorea/hemiballismus in the monkey. Studies on the intracerebral site of action in a drug-induced dyskinesia.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Chorea and myoclonus in the monkey induced by gamma-aminobutyric acid antagonism in the lentiform complex. The site of drug action and a hypothesis for the neural mechanisms of chorea

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Organization of corticostriatal motor inputs in monkey putamen.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Serial 1H-NMR spectroscopy study of metabolic impairment in primates chronically treated with the succinate dehydrogenase inhibitor 3-nitropropionic acid.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Transgenic monkeys produced by retroviral gene transfer into mature oocytes

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

MRI-stereotactical approach for neural grafting in basal ganglia disorders.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Delayed onset of progressive dystonia following subacute 3-nitropropionic acid treatment in Cebus apella monkeys

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

A rating scale for Gilles de la Tourette's syndrome: description, reliability, and validity data

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

cFos immunoreactivity is enhanced with biotin amplification

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300185

7 January 2021

Identifiers

DOI

10.1038/SJ.MT.6300185

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11 December 2017

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