Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation (Q45306368)

11 December 2017

Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation (English)

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11 December 2017

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Jenny Carmichael

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11 December 2017

Katherine L Sugars

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2

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11 December 2017

Yi Ping Bao

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3

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11 December 2017

David C Rubinsztein

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4

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11 December 2017

language of work or name

English

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publication date

3 July 2002

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Journal of Biological Chemistry

11 December 2017

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11 December 2017

277

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11 December 2017

33791-33798

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11 December 2017

37

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The molecular biology of Huntington's disease

11 December 2017

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204861200

Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204861200

Protein fate in neurodegenerative proteinopathies: polyglutamine diseases join the (mis)fold

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204861200

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

GSK3 takes centre stage more than 20 years after its discovery

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

beta-catenin is a target for the ubiquitin-proteasome pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Biochemical interactions in the wnt pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

A versatile transcriptional effector of Wingless signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Curbing the nuclear activities of beta-catenin. Control over Wnt target gene expression

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204861200

Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204861200

Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204861200

Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204861200

Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204861200

Molecular mechanisms underlying mood stabilization in manic-depressive illness: the phenotype challenge

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204861200

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204861200

21 January 2018

The renaissance of GSK3

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https://api.crossref.org/works/10.1074%2FJBC.M204861200

21 January 2018

Identifiers

DOI

10.1074/JBC.M204861200

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11 December 2017

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